Afficher la notice abrégée

A Bottom-Up Approach to Red-Emitting Molecular-Based Nanoparticles with Natural Stealth Properties and their Use for Single-Particle Tracking Deep in Brain Tissue.

dc.rights.licenseopenen_US
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorROSENDALE, Morgane
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorFLORES, Jessica
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorPAVIOLO, Chiara
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorPAGANO, Paolo
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorDANIEL, Jonathan
hal.structure.identifierInterdisciplinary Institute for Neuroscience / Institut interdisciplinaire de neurosciences [Bordeaux] [IINS]
dc.contributor.authorFERREIRA, Joana
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorVERLHAC, Jean-Baptiste
IDREF: 034239642
hal.structure.identifierInterdisciplinary Institute for Neuroscience / Institut interdisciplinaire de neurosciences [Bordeaux] [IINS]
dc.contributor.authorGROC, Laurent
hal.structure.identifierLaboratoire Photonique, Numérique et Nanosciences [LP2N]
dc.contributor.authorCOGNET, Laurent
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorBLANCHARD-DESCE, Mireille
dc.date.accessioned2021-08-26T14:52:35Z
dc.date.available2021-08-26T14:52:35Z
dc.date.issued2021-06-01
dc.identifier.issn1521-4095en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/110223
dc.description.abstractEnFluorescent nanoparticles dedicated to bioimaging applications should possess specific properties that have to be maintained in the aqueous, reactive, and crowded biological environment. These include chemical and photostability, small size (on the scale of subcellular structures), biocompatibility, high brightness, and good solubility. The latter is a major challenge for inorganic nanoparticles, which require surface coating to be made water soluble. Molecular-based fluorescent organic nanoparticles (FONs) may prove a promising, spontaneously water-soluble alternative, whose bottom-up design allows for the fine-tuning of individual properties. Here, the critical challenge of controlling the interaction of nanoparticles with cellular membranes is addressed. This is a report on bright, size-tunable, red-emitting, naturally stealthy FONs that do not require the use of antifouling agents to impede interactions with cellular membranes. As a proof of concept, single FONs diffusing up to 150 µm deep in brain tissue are imaged and tracked.
dc.description.sponsorshipRegulation physiopathologique de la dynamique des recepteurs NMDA dans l'hippocampe - ANR-15-CE16-0004en_US
dc.description.sponsorshipInitiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003en_US
dc.language.isoENen_US
dc.subjectBrain extracellular space; Brightness
dc.subjectFluorescence
dc.subjectOrganic nanoparticles
dc.subjectSingle-particle tracking
dc.subjectStealth
dc.title.enA Bottom-Up Approach to Red-Emitting Molecular-Based Nanoparticles with Natural Stealth Properties and their Use for Single-Particle Tracking Deep in Brain Tissue.
dc.title.alternativeAdv Materen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/adma.202006644en_US
dc.subject.halSciences de l'ingénieur [physics]/Matériaux
dc.identifier.pubmed33890332en_US
dc.description.sponsorshipEuropeADVANCED LABORATORY FOR THE NANO-ANALYSIS OF NOVEL FUNCTIONAL MATERIALSen_US
bordeaux.journalAdvanced Materialsen_US
bordeaux.pagee2006644en_US
bordeaux.volume33en_US
bordeaux.hal.laboratoriesInstitut des Sciences Moléculaires (ISM) - UMR 5255en_US
bordeaux.issue22en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-03281914
hal.exportfalse
workflow.import.sourcepubmed
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Advanced%20Materials&rft.date=2021-06-01&rft.volume=33&rft.issue=22&rft.spage=e2006644&rft.epage=e2006644&rft.eissn=1521-4095&rft.issn=1521-4095&rft.au=ROSENDALE,%20Morgane&FLORES,%20Jessica&PAVIOLO,%20Chiara&PAGANO,%20Paolo&DANIEL,%20Jonathan&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
ISM_AdvMater_2021_Rosendale.pdf
Taille:
401.8Ko
Format:
PDF
Voir/Ouvrir
Thumbnail
Nom:
ISM_AdvMater_2021_Rosendale_SI.pdf
Taille:
830.0Ko
Format:
PDF
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée