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The diversity of platelet microparticles

dc.contributor.authorBOILARD, Eric
dc.contributor.authorDUCHEZ, Anne-Claire
dc.contributor.authorBRISSON, Alain
dc.date.accessioned2020-09-03T08:02:20Z
dc.date.available2020-09-03T08:02:20Z
dc.date.issued2015
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11014
dc.description.abstractEnPURPOSE OF REVIEW: Platelet microparticles are small extracellular vesicles abundant in blood. The present review will introduce the mechanisms underlying the generation of microparticles, and will describe the diverse microparticle subtypes identified to date. The most appropriate methodologies used to distinguish microparticle subtypes will be also presented. RECENT FINDINGS: Both the megakaryocytes and platelets can generate microparticles. Circulating microparticles originating from megakaryocytes are distinguished from those derived from activated platelets by the presence of CD62P, LAMP-1, and immunoreceptor-based activation motif receptors. Close examination of platelet activation has shed light on a novel mechanism leading to microparticle production. Under physiologic flow, microparticles bud off from long membrane strands formed by activated platelets. Furthermore, mounting evidence supports the notion of microparticle heterogeneity. Platelet microparticles are commonly characterized by the expression of surface platelet antigens and phosphatidylserine. In fact, only a fraction of platelet microparticles harbor phosphatidylserine, and a distinct subset contains respiratory-competent mitochondria. During disease, the microparticle surface may undergo posttranslational modifications such as citrullination, further supporting the concept of microparticle diversity. SUMMARY: An appreciation of the microparticle heterogeneity will support their development as potential biomarkers and may reveal functions unique to each microparticle subtype in health and disease.
dc.language.isoen
dc.title.enThe diversity of platelet microparticles
dc.typeArticle de revue
dc.identifier.doi10.1097/moh.0000000000000166
dc.subject.halChimie/Matériaux
bordeaux.journalCurrent Opinion in Hematology
bordeaux.page437-44
bordeaux.volume22
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issue5
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Current%20Opinion%20in%20Hematology&rft.date=2015&rft.volume=22&rft.issue=5&rft.spage=437-44&rft.epage=437-44&rft.au=BOILARD,%20Eric&DUCHEZ,%20Anne-Claire&BRISSON,%20Alain&rft.genre=article


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