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Shaping quaternary assemblies of water-soluble non-peptide helical foldamers by sequence manipulation

dc.contributor.authorCOLLIE, Gavin W.
dc.contributor.authorPULKA-ZIACH, Karolina
dc.contributor.authorLOMBARDO, Caterina M.
dc.contributor.authorFREMAUX, Juliette
dc.contributor.authorROSU, Frederic
dc.contributor.authorDECOSSAS, Marion
dc.contributor.authorMAURAN, Laura
dc.contributor.authorLAMBERT, Olivier
dc.contributor.authorGABELICA, Valérie
dc.contributor.authorMACKERETH, Cameron D.
dc.contributor.authorGUICHARD, Gilles
IDREF: 084339268
dc.date.accessioned2020-09-03T08:02:16Z
dc.date.available2020-09-03T08:02:16Z
dc.date.issued2015
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11001
dc.description.abstractEnThe design and construction of biomimetic self-assembling systems is a challenging yet potentially highly rewarding endeavour that contributes to the development of new biomaterials, catalysts, drug-delivery systems and tools for the manipulation of biological processes. Significant progress has been achieved by engineering self-assembling DNA-, protein- and peptide-based building units. However, the design of entirely new, completely non-natural folded architectures that resemble biopolymers ('foldamers') and have the ability to self-assemble into atomically precise nanostructures in aqueous conditions has proved exceptionally challenging. Here we report the modular design, formation and structural elucidation at the atomic level of a series of diverse quaternary arrangements formed by the self-assembly of short amphiphilic alpha-helicomimetic foldamers that bear proteinaceous side chains. We show that the final quaternary assembly can be controlled at the sequence level, which permits the programmed formation of either discrete helical bundles that contain isolated cavities or pH-responsive water-filled channels with controllable pore diameters.
dc.language.isoen
dc.title.enShaping quaternary assemblies of water-soluble non-peptide helical foldamers by sequence manipulation
dc.typeArticle de revue
dc.identifier.doi10.1038/nchem.2353
dc.subject.halChimie/Matériaux
bordeaux.journalNature chemistry
bordeaux.page871-8
bordeaux.volume7
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issue11
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
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