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All-optical broadband ultrasonography of single cells

dc.contributor.authorDEHOUX, T.
dc.contributor.authorGHANEM, M. Abi
dc.contributor.authorZOUANI, O. F.
dc.contributor.authorRAMPNOUX, J. M.
dc.contributor.authorGUILLET, Y.
dc.contributor.authorDILHAIRE, S.
dc.contributor.authorDURRIEU, Marie‐Christine
dc.contributor.authorAUDOIN, B.
dc.date.accessioned2020-09-03T08:02:13Z
dc.date.available2020-09-03T08:02:13Z
dc.date.issued2015
dc.identifier.issn2045-2322
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10992
dc.description.abstractEnCell mechanics play a key role in several fundamental biological processes, such as migration, proliferation, differentiation and tissue morphogenesis. In addition, many diseased conditions of the cell are correlated with altered cell mechanics, as in the case of cancer progression. For this there is much interest in methods that can map mechanical properties with a sub-cell resolution. Here, we demonstrate an inverted pulsed opto-acoustic microscope (iPOM) that operates in the 10 to 100 GHz range. These frequencies allow mapping quantitatively cell structures as thin as 10 nm and resolving the fibrillar details of cells. Using this non-invasive all-optical system, we produce high-resolution images based on mechanical properties as the contrast mechanisms, and we can observe the stiffness and adhesion of single migrating stem cells. The technique should allow transferring the diagnostic and imaging abilities of ultrasonic imaging to the single-cell scale, thus opening new avenues for cell biology and biomaterial sciences.
dc.language.isoen
dc.title.enAll-optical broadband ultrasonography of single cells
dc.typeArticle de revue
dc.identifier.doi10.1038/srep08650
dc.subject.halChimie/Matériaux
bordeaux.journalScientific Reports
bordeaux.volume5
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2015&rft.volume=5&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=DEHOUX,%20T.&GHANEM,%20M.%20Abi&ZOUANI,%20O.%20F.&RAMPNOUX,%20J.%20M.&GUILLET,%20Y.&rft.genre=article


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