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Dual and Opposite Effects of hRAD51 Chemical Modulation on HIV-1 Integration

dc.contributor.authorTHIERRY, Sylvain
dc.contributor.authorBENLEULMI, Mohamed Salah
dc.contributor.authorSINZELLE, Ludivine
dc.contributor.authorTHIERRY, Eloise
dc.contributor.authorCALMELS, Christina
dc.contributor.authorCHAIGNEPAIN, Stephane
dc.contributor.authorWAFFO TEGUO, Pierre
dc.contributor.authorMERILLON, Jean-Michel
dc.contributor.authorBUDKE, Brian
dc.contributor.authorPASQUET, Jean-Max
dc.contributor.authorLITVAK, Simon
dc.contributor.authorCIUFFI, Angela
dc.contributor.authorSUNG, Patrick
dc.contributor.authorCONNELL, Philip
dc.contributor.authorHAUBER, Ilona
dc.contributor.authorHAUBER, Joachim
dc.contributor.authorANDREOLA, Marie-Line
dc.contributor.authorDELELIS, Olivier
dc.contributor.authorPARISSI, Vincent
dc.date.accessioned2020-09-03T08:02:12Z
dc.date.available2020-09-03T08:02:12Z
dc.date.issued2015
dc.identifier.issn1074-5521
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10987
dc.description.abstractEnThe cellular DNA repair hRAD51 protein has been shown to restrict HIV-1 integration both in vitro and in vivo. To investigate its regulatory functions, we performed a pharmacological analysis of the retroviral integration modulation by hRAD51. We found that, in vitro, chemical activation of hRAD51 stimulates its integration inhibitory properties, whereas inhibition of hRAD51 decreases the integration restriction, indicating that the modulation of HIV-1 integration depends on the hRAD51 recombinase activity. Cellular analyses demonstrated that cells exhibiting high hRAD51 levels prior to de novo infection are more resistant to integration. On the other hand, when hRAD51 was activated during integration, cells were more permissive. Altogether, these data establish the functional link between hRAD51 activity and HIV-1 integration. Our results highlight the multiple and opposite effects of the recombinase during integration and provide new insights into the cellular regulation of HIV-1 replication.
dc.language.isoen
dc.title.enDual and Opposite Effects of hRAD51 Chemical Modulation on HIV-1 Integration
dc.typeArticle de revue
dc.identifier.doi10.1016/j.chembiol.2015.04.020
dc.subject.halChimie/Matériaux
bordeaux.journalChemistry & Biology
bordeaux.page712-723
bordeaux.volume22
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issue6
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Chemistry%20&%20Biology&rft.date=2015&rft.volume=22&rft.issue=6&rft.spage=712-723&rft.epage=712-723&rft.eissn=1074-5521&rft.issn=1074-5521&rft.au=THIERRY,%20Sylvain&BENLEULMI,%20Mohamed%20Salah&SINZELLE,%20Ludivine&THIERRY,%20Eloise&CALMELS,%20Christina&rft.genre=article


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