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Premature Skin Aging Features Rescued by Inhibition of NADPH Oxidase Activity in XPC-Deficient Mice

dc.contributor.authorHOSSEINI, Mohsen
dc.contributor.authorMAHFOUF, Walid
dc.contributor.authorSERRANO-SANCHEZ, Martin
dc.contributor.authorRAAD, Houssam
dc.contributor.authorHARFOUCHE, Ghida
dc.contributor.authorBONNEU, Marc
dc.contributor.authorCLAVEROL, Stephane
dc.contributor.authorMAZURIER, Frederic
dc.contributor.authorROSSIGNOL, Rodrigue
dc.contributor.authorTAIEB, Alain
dc.contributor.authorREZVANI, Hamid Reza
dc.date.accessioned2020-09-03T08:02:08Z
dc.date.available2020-09-03T08:02:08Z
dc.date.issued2015
dc.identifier.issn0022-202X
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10974
dc.description.abstractEnXeroderma pigmentosum type C (XP-C) is characterized mostly by a predisposition to skin cancers and accelerated photoaging, but little is known about premature skin aging in this disease. By comparing young and old mice, we found that the level of progerin and p16(INK4a) expression, beta-galactosidase activity, and reactive oxygen species, which increase with age, were higher in young Xpc(-/-) mice than in young Xpc(+/+) ones. The expression level of mitochondrial complexes and mitochondrial functions in the skin of young Xpc(-/-) was as low as in control aged Xpc(+/+) animals. Furthermore, the metabolic profile in young Xpc(-/-) mice resembled that found in aged Xpc(+/+) mice. Furthermore, premature skin aging features in young Xpc(-/-) mice were mostly rescued by inhibition of nicotinamide adenine dinucleotide phosphate oxidase 1 (NOX1) activity by using a NOX1 peptide inhibitor, suggesting that the continuous oxidative stress due to overactivation of NOX1 has a causative role in the underlying pathophysiology.
dc.language.isoen
dc.title.enPremature Skin Aging Features Rescued by Inhibition of NADPH Oxidase Activity in XPC-Deficient Mice
dc.typeArticle de revue
dc.identifier.doi10.1038/jid.2014.511
dc.subject.halChimie/Matériaux
bordeaux.journalJOURNAL OF INVESTIGATIVE DERMATOLOGY
bordeaux.page1108-1118
bordeaux.volume135
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issue4
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=JOURNAL%20OF%20INVESTIGATIVE%20DERMATOLOGY&rft.date=2015&rft.volume=135&rft.issue=4&rft.spage=1108-1118&rft.epage=1108-1118&rft.eissn=0022-202X&rft.issn=0022-202X&rft.au=HOSSEINI,%20Mohsen&MAHFOUF,%20Walid&SERRANO-SANCHEZ,%20Martin&RAAD,%20Houssam&HARFOUCHE,%20Ghida&rft.genre=article


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