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Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study

dc.contributor.authorLEFEVRE, Marie
dc.contributor.authorRACEDO, Silvia M.
dc.contributor.authorRIPERT, Gabrielle
dc.contributor.authorHOUSEZ, Beatrice
dc.contributor.authorCAZAUBIEL, Murielle
dc.contributor.authorMAUDET, Corinne
dc.contributor.authorJUESTEN, Peter
dc.contributor.authorMARTEAU, Philippe
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorURDACI, Maria C.
ORCID: 0000-0002-0868-0050
IDREF: 033307679
dc.date.accessioned2020-09-03T08:02:04Z
dc.date.available2020-09-03T08:02:04Z
dc.date.issued2015
dc.identifier.issn1742-4933
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10961
dc.description.abstractEnBackground: Bacillus probiotics health benefits have been until now quite poorly studied in the elderly population. This study aimed to assess the effects of Bacillus subtilis CU1 consumption on immune stimulation and resistance to common infectious disease (CID) episodes in healthy free-living seniors. Results: One hundred subjects aged 60-74 were included in this randomized, double-blind, placebo-controlled, parallel-arms study. Subjects consumed either the placebo or the probiotic (2.10(9) B. subtilis CU1 spores daily) by short periodical courses of 10 days intermittently, alternating 18-day course of break. This scheme was repeated 4 times during the study. Symptoms of gastrointestinal and upper/lower respiratory tract infections were recorded daily by the subjects throughout the study (4 months). Blood, saliva and stool samples were collected in a predefined subset of the first forty-four subjects enrolled in the study. B. subtilis CU1 supplementation did not statistically significantly decrease the mean number of days of reported CID symptoms over the 4-month of study (probiotic group: 5.1 (7.0) d, placebo group: 6.6 (7.3) d, P = 0.2015). However, in the subset of forty-four randomized subjects providing biological samples, we showed that consumption of B. subtilis CU1 significantly increased fecal and salivary secretory IgA concentrations compared to the placebo. A post-hoc analysis on this subset showed a decreased frequency of respiratory infections in the probiotc group compared to the placebo group. Conclusion: Taken together, our study provides evidence that B. subtilis CU1 supplementation during the winter period may be a safe effective way to stimulate immune responses in elderly subjects.
dc.language.isoen
dc.title.enProbiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study
dc.typeArticle de revue
dc.identifier.doi10.1186/s12979-015-0051-y
dc.subject.halChimie/Matériaux
bordeaux.journalImmunity & Ageing
bordeaux.volume12
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Immunity%20&%20Ageing&rft.date=2015&rft.volume=12&rft.eissn=1742-4933&rft.issn=1742-4933&rft.au=LEFEVRE,%20Marie&RACEDO,%20Silvia%20M.&RIPERT,%20Gabrielle&HOUSEZ,%20Beatrice&CAZAUBIEL,%20Murielle&rft.genre=article


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