Afficher la notice abrégée

Effect of iron on the probiotic properties of the vaginal isolate Lactobacillus jensenii CECT 4306

dc.contributor.authorMARTIN, Rebeca
dc.contributor.authorSANCHEZ, Borja
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorURDACI, Maria C.
ORCID: 0000-0002-0868-0050
IDREF: 033307679
dc.contributor.authorLANGELLA, Philippe
dc.contributor.authorSUAREZ, Juan E.
dc.contributor.authorBERMUDEZ-HUMARAN, Luis G.
dc.date.accessioned2020-09-03T08:02:02Z
dc.date.available2020-09-03T08:02:02Z
dc.date.issued2015
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10955
dc.description.abstractEnThe vaginal microbiota of healthy, fertile women is dominated by lactobacilli. As a defence mechanism, these bacteria produce H2O2 to discourage colonization of the vagina by undesirable micro-organisms. In particular, Lactobacillus jensenii CECT 4306 is a strong producer of H2O2 and has been found to protect itself from the bactericidal effects of this compound through the activity of extracellular peroxidases. However, this peroxidase activity is dependent on the presence of Fe(3+), which is found in elevated concentrations in the vaginal mucosa as a consequence of the menstrual discharge. The aim of the present work was to evaluate whether Fe(3+) is able to modulate other potential probiotic properties of strain 4306. We found that Fe(3+) enhances the adhesion of L. jensenii CECT 4306 to mucin and to HT-29 and HT-29 MTX cells, and, in addition, improves the anti-inflammatory profile, as judged by an increase in the ratio of IL-10/IL-12p70 that were secreted by macrophages. A comparison of total, secreted and surface proteins produced in the presence and absence of Fe(3+) revealed significant differences in the concentration of the moonlighting protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH). In conclusion, Fe(3+) seems to improve the probiotic characteristics of L. jensenii CECT 4306, and future research of the interactions of this strain with its vaginal environment may reveal further information about different aspects of its probiotic potential.
dc.language.isoen
dc.title.enEffect of iron on the probiotic properties of the vaginal isolate Lactobacillus jensenii CECT 4306
dc.typeArticle de revue
dc.identifier.doi10.1099/mic.0.000044
dc.subject.halChimie/Matériaux
bordeaux.journalMicrobiology (Reading, England)
bordeaux.page708-18
bordeaux.volume161
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issuePt 4
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Microbiology%20(Reading,%20England)&rft.date=2015&rft.volume=161&rft.issue=Pt%204&rft.spage=708-18&rft.epage=708-18&rft.au=MARTIN,%20Rebeca&SANCHEZ,%20Borja&URDACI,%20Maria%20C.&LANGELLA,%20Philippe&SUAREZ,%20Juan%20E.&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée