Afficher la notice abrégée

Specific Anti-Leukemic Activity of the Peptide Warnericin RK and Analogues and Visualization of Their Effect on Cancer Cells by Chemical Raman Imaging

dc.contributor.authorLOISEAU, Clemence
dc.contributor.authorAUGENSTREICH, Jacques
dc.contributor.authorMARCHAND, Adrienne
dc.contributor.authorHARTE, Etienne
dc.contributor.authorGARCIA, Martine
dc.contributor.authorVERDON, Julien
dc.contributor.authorMESNIL, Marc
dc.contributor.authorLECOMTE, Sophie
dc.contributor.authorBERJEAUD, Jean-Marc
dc.date.accessioned2020-09-03T07:56:12Z
dc.date.available2020-09-03T07:56:12Z
dc.date.issued2016
dc.identifier.issn1932-6203
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10845
dc.description.abstractEnAntimicrobial peptides can be used as therapeutic agents against cancer cells. Warnericin RK and derivatives (WarnG20D and WarnF14V) were tested on various, solid tumor or leukemia, cancer cells. These peptides appeared to be cytotoxic on all the cell types tested, cancerous as well healthy, but very interestingly displayed no deleterious effect on healthy mononuclear cells. The mode of action of the peptide was proposed to be membranolytic, using chemical Raman imaging. Addition of peptide induced a large disorganization of the membrane leading to the loss of the content of inner compartments of Jurkat cell, whereas no effect was observed on the healthy mononuclear cells. The less hemolytic peptides WarnG20D and WarnF14V could be good candidates for the leukemia treatment.
dc.language.isoen
dc.title.enSpecific Anti-Leukemic Activity of the Peptide Warnericin RK and Analogues and Visualization of Their Effect on Cancer Cells by Chemical Raman Imaging
dc.typeArticle de revue
dc.identifier.doi10.1371/journal.pone.0162007
dc.subject.halChimie/Matériaux
bordeaux.journalPloS one
bordeaux.pagee0162007
bordeaux.volume11
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issue9
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PloS%20one&rft.date=2016&rft.volume=11&rft.issue=9&rft.spage=e0162007&rft.epage=e0162007&rft.eissn=1932-6203&rft.issn=1932-6203&rft.au=LOISEAU,%20Clemence&AUGENSTREICH,%20Jacques&MARCHAND,%20Adrienne&HARTE,%20Etienne&GARCIA,%20Martine&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée