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Anatomy of an Oligourea Six-Helix Bundle

dc.relation.isnodouble9dfcc4de-caa7-40ef-b463-804e187beb78*
dc.contributor.authorLOMBARDO, Caterina M.
dc.contributor.authorCOLLIE, Gavin W.
dc.contributor.authorPULKA-ZIACH, Karolina
dc.contributor.authorROSU, Frederic
dc.contributor.authorGABELICA, Valérie
dc.contributor.authorMACKERETH, Cameron D.
dc.contributor.authorGUICHARD, Gilles
IDREF: 084339268
dc.date.accessioned2020-09-03T07:56:12Z
dc.date.available2020-09-03T07:56:12Z
dc.date.issued2016
dc.identifier.issn0002-7863
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10844
dc.description.abstractEnNon-natural synthetic oligomers that adopt well-defined secondary structures (i.e., foldamers) represent appealing components for the fabrication of bioinspired self assembled architectures at the nanometer scale. Recently, peptidomimetic N,N'-linked oligourea helices have been designed de novo with the ability to fold into discrete helix bundles in aqueous conditions. In order to gain better insight into the determinants of oligourea helix bundle formation, we have investigated the sequence-to-structure relationship of an 11-mer oligourea previously shown to assemble into a six-helix bundle. Using circular dichroism, NMR spectroscopy, native mass-spectrometry and X-ray crystallography, we studied how bundle formation was affected by systematic replacement of the hydrophobic surface of the oligourea helix with either polar or different hydrophobic side chains. The molecular information gathered here has revealed several key requirements for foldamer bundle formation in aqueous conditions, and provides valuable insight toward the development of foldamer quaternary assemblies with improved (bio)physical properties and divergent topologies.
dc.language.isoen
dc.title.enAnatomy of an Oligourea Six-Helix Bundle
dc.typeArticle de revue
dc.subject.halChimie/Matériaux
bordeaux.journalJournal of the American Chemical Society
bordeaux.page10522-10530
bordeaux.volume138
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issue33
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
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