G-Quadruplexes Light up Localized DNA Circuits
| dc.contributor.author | MENDOZA, Oscar | |
| dc.contributor.author | MERGNY, Jean-Louis | |
| dc.contributor.author | AIME, Jean-Pierre | |
| dc.contributor.author | ELEZGARAY, Juan | |
| dc.date.accessioned | 2020-09-03T07:56:11Z | |
| dc.date.available | 2020-09-03T07:56:11Z | |
| dc.date.issued | 2016 | |
| dc.identifier.issn | 1530-6984 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/10838 | |
| dc.description.abstractEn | DNA circuits tethered to nanoplatforms can perform cascade reactions for signal amplification. One DNA single strand activates a strand-displacement cascade generating numerous outputs, and therefore amplifying the signal. These localized circuits present, however, an important limitation: the spontaneous activation of the cascade reaction. Current methods to stabilize these circuits employ combination of protective DNA strands, which need to be removed to activate the device. This protection-deprotection process generates an important amount of unwanted side reactions. This is indeed an important limitation for the large potential application of these amplification circuits. In the present work, G-quadruplex DNA structures were used to stabilize localized DNA circuits. This new protocol generates nanoplatforms that no longer requires protective-deprotective systems and is therefore completely neutral to the sample. In addition, cations such as Pb2+ or Ca2+ can be also employed to activate the device enlarging the potential applications from biosensors devices to metal detector sensors. | |
| dc.language.iso | en | |
| dc.title.en | G-Quadruplexes Light up Localized DNA Circuits | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1021/acs.nanolett.5b04354 | |
| dc.subject.hal | Chimie/Matériaux | |
| bordeaux.journal | Nano Letters | |
| bordeaux.page | 624-628 | |
| bordeaux.volume | 16 | |
| bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | * |
| bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248) | |
| bordeaux.issue | 1 | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nano%20Letters&rft.date=2016&rft.volume=16&rft.issue=1&rft.spage=624-628&rft.epage=624-628&rft.eissn=1530-6984&rft.issn=1530-6984&rft.au=MENDOZA,%20Oscar&MERGNY,%20Jean-Louis&AIME,%20Jean-Pierre&ELEZGARAY,%20Juan&rft.genre=article |
Fichier(s) constituant ce document
| Fichiers | Taille | Format | Vue |
|---|---|---|---|
|
Il n'y a pas de fichiers associés à ce document. |
|||