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Parameter estimates for trends and patterns of excess mortality among persons on ART in high-income european settings

dc.rights.licenseopenen_US
dc.contributor.authorTRICKEY, A.
dc.contributor.authorVAN SIGHEM, A.
dc.contributor.authorSTOVER, J.
dc.contributor.authorABGRALL, S.
dc.contributor.authorGRABAR, S.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBONNET, Fabrice
dc.contributor.authorBERENGUER, J.
dc.contributor.authorWYEN, C.
dc.contributor.authorCASABONA, J.
dc.contributor.authorD'ARMINIO MONFORTE, A.
dc.contributor.authorCAVASSINI, M.
dc.contributor.authorDEL AMO, J.
dc.contributor.authorZANGERLE, R.
dc.contributor.authorGILL, M. J.
dc.contributor.authorOBEL, N.
dc.contributor.authorSTERNE, J. A. C.
dc.contributor.authorMAY, M. T.
dc.date.accessioned2020-07-24T09:44:35Z
dc.date.available2020-07-24T09:44:35Z
dc.date.issued2019-12-15
dc.identifier.issn1473-5571 (Electronic) 0269-9370 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10677
dc.description.abstractEnINTRODUCTION: HIV cohort data from high-income European countries were compared to the UNAIDS Spectrum modelling parameters for these same countries to validate mortality rates and excess mortality estimates for people living with HIV (PLHIV) on antiretroviral therapy (ART). METHODS: Data from 2000-2015 were analysed from the Antiretroviral Therapy Cohort Collaboration (ART-CC) for Austria, Denmark, France, Italy, the Netherlands, Spain, and Switzerland. Flexible parametric models were used to compare All-cause mortality rates in the ART-CC and Spectrum. The percentage of AIDS-related deaths and excess mortality (both are the same within Spectrum) were compared, with excess mortality defined as that in excess of the general population mortality. RESULTS: Analyses included 94026 PLHIV with 585784 person-years of follow-up, from which there were 5515 deaths. All-cause annual mortality rates in Spectrum for 2000-2003 were 0.0121, reducing to 0.0078 in 2012-2015, whilst the ART-CC's corresponding annual mortality rates were 0.0151 (95% confidence interval [95%CI]: 0.0130-0.0171) reducing to 0.0049 (95%CI: 0.0039-0.0060). The percentage of AIDS-related deaths in Spectrum was 74.7% in 2000-2003, dropping to 43.6% in 2012-15. In the ART-CC, AIDS-related mortality comprised 45.3% (95%CI: 38.4%-52.9%) of mortality in 2000-2003 and 26.7% (95%CI: 19.0%, 46.0%) between 2012-2015. Excess mortality in the ART-CC was broadly similar to the Spectrum estimates, dropping from 75.3% (95%CI: 60.3%-95.2%) in 2000-2003 to 30.7% (95%CI: 25.5%-63.7%) in 2012-2015. CONCLUSIONS: All-cause mortality assumptions for PLHIV on ART in high-income European settings should be adjusted in Spectrum to be higher in 2000-2003 and decline more quickly to levels currently captured for recent years.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/us/
dc.subject.enMORPH3Eus
dc.title.enParameter estimates for trends and patterns of excess mortality among persons on ART in high-income european settings
dc.title.alternativeAIDSen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/qad.0000000000002387
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31764067en_US
bordeaux.journalAIDS. Official journal of the international AIDS Societyen_US
bordeaux.pageS271-S281en_US
bordeaux.volume33en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issueSuppl 3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03162415
hal.version1
hal.date.transferred2021-03-08T13:50:55Z
hal.exporttrue
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