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Functioning and cognitive characteristics of clozapine users referred to psychosocial rehabilitation centers: A REHABase cohort study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorVERDOUX, Helene
dc.contributor.authorQUILES, Clelia
dc.contributor.authorCERVELLO, Sophie
dc.contributor.authorDUBREUCQ, Julien
dc.contributor.authorBON, L.
dc.contributor.authorMASSOUBRE, Catherine
dc.contributor.authorPOMMIER, R.
dc.contributor.authorLEGROS-LAFARGE, Emilie
dc.contributor.authorJAAFARI, N.
dc.contributor.authorGUILLARD-BOUHET, Nathalie
dc.contributor.authorCHEREAU-BOUDET, I.
dc.contributor.authorCOUHET, Geoffroy
dc.contributor.authorPLASSE, Julien
dc.contributor.authorFRANCK, Nicolas
dc.date.accessioned2020-07-16T13:12:59Z
dc.date.available2020-07-16T13:12:59Z
dc.date.issued2019-11
dc.identifier.issn1872-7123 (Electronic) 0165-1781 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10497
dc.description.abstractEnOBJECTIVES: To explore whether clozapine users have specific rehabilitation needs compared to users of other antipsychotics. METHODS: The study was performed using the REHABase collecting data on persons referred to a French network of psychosocial rehabilitation centers. It was restricted to persons with schizophrenia spectrum disorder using antipsychotics. Multivariate analyses were used to compare baseline functioning and cognitive characteristics in clozapine users vs. users of other antipsychotics. RESULTS: Of the 675 patients identified in the REHABase, one out of ten (n=70) used clozapine. Compared to users of other antipsychotics, clozapine users had been more frequently hospitalized in psychiatry and presented less frequently with psychoactive substance use. Functional measures did not significantly differ between the two groups. Clozapine users had poorer short-term verbal memory performance than users of other antipsychotics and did not differ on executive performance. CONCLUSION: Clozapine users may reach a recovery level comparable to that obtained in persons without treatment-resistant schizophrenia. In order to reduce the negative impact of memory deficits on the recovery process of clozapine users, it is necessary to optimize their psychotropic treatment and to promote their access to cognitive remediation programs addressing their specific needs.
dc.language.isoENen_US
dc.subject.enPharmacoEpi-Drugs
dc.title.enFunctioning and cognitive characteristics of clozapine users referred to psychosocial rehabilitation centers: A REHABase cohort study
dc.title.alternativePsychiatry Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.psychres.2019.112543en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31493715en_US
bordeaux.journalPsychiatry Researchen_US
bordeaux.page112543en_US
bordeaux.volume281en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03209533
hal.version1
hal.date.transferred2021-04-27T09:45:04Z
hal.exporttrue
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