Use of dietary supplements containing soy isoflavones and breast cancer risk among women aged >50 y: a prospective study
| dc.rights.license | open | en_US |
| dc.contributor.author | TOUILLAUD, M. | |
| dc.contributor.author | GELOT, A. | |
| dc.contributor.author | MESRINE, S. | |
| dc.contributor.author | BENNETAU, Catherine | |
| dc.contributor.author | CLAVEL-CHAPELON, F. | |
| dc.contributor.author | ARVEUX, P. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BONNET, Fabrice | |
| dc.contributor.author | GUNTER, M. | |
| dc.contributor.author | BOUTRON-RUAULT, M. C. | |
| dc.contributor.author | FOURNIER, A. | |
| dc.date.accessioned | 2020-07-15T09:08:15Z | |
| dc.date.available | 2020-07-15T09:08:15Z | |
| dc.date.issued | 2019-03-01 | |
| dc.identifier.issn | 0002-9165 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/10476 | |
| dc.description.abstractEn | BACKGROUND: Soy-based dietary supplements have been promoted as natural alternatives to menopausal hormone therapy, but their potential effect on breast cancer development is controversial. OBJECTIVES: We examined the relation between the consumption of soy supplements and the risk of breast cancer, overall and by tumor hormone receptor status, among women aged >50 y. METHODS: In total, 76,442 women from the Etude Epidemiologique aupres de Femmes de la Mutuelle Generale de l'Education Nationale (E3N) cohort, born between 1925 and 1950, were followed from 2000 to 2011 (11.2 y on average, starting at a mean age of 59.5 y; 3608 incident breast cancers), with soy supplement use assessed every 2-3 y. HRs of breast cancer were estimated with the use of multivariable Cox models. RESULTS: Compared with never using soy supplements, the HRs associated with current use of soy supplements were 0.92 (95% CI: 0.76, 1.11) for all, 0.78 (95% CI: 0.60, 0.99) for estrogen receptor (ER)-positive, and 2.01 (95% CI: 1.41, 2.86) for ER-negative breast cancers. There was no association between past use of soy supplements and breast cancer. HRs for current use were 1.36 (95% CI: 0.95, 1.93) and 0.82 (95% CI: 0.65, 1.02) among women with and without a family history of breast cancer, respectively (P-interaction = 0.03) and 1.06 (95% CI: 0.87, 1.30) >/=5 y after menopause compared with 0.50 (95% CI: 0.31, 0.81) in premenopause or </=5 y postmenopause (P-interaction = 0.04). CONCLUSIONS: In this cohort of women aged >50 y, we report opposing associations of soy supplements with ER-positive and ER-negative breast cancer risk. Our results also caution against the use of these supplements in women with a family history of breast cancer. Whether the risk profile of soy supplements could be more favorable among premenopausal or recently postmenopausal women deserves further investigation. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | MORPH3Eus | |
| dc.title.en | Use of dietary supplements containing soy isoflavones and breast cancer risk among women aged >50 y: a prospective study | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/ajcn/nqy313 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 30831601 | en_US |
| bordeaux.journal | American Journal of Clinical Nutrition | en_US |
| bordeaux.page | 597-605 | en_US |
| bordeaux.volume | 109 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.issue | 3 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03212254 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-04-29T12:28:24Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=American%20Journal%20of%20Clinical%20Nutrition&rft.date=2019-03-01&rft.volume=109&rft.issue=3&rft.spage=597-605&rft.epage=597-605&rft.eissn=0002-9165&rft.issn=0002-9165&rft.au=TOUILLAUD,%20M.&GELOT,%20A.&MESRINE,%20S.&BENNETAU,%20Catherine&CLAVEL-CHAPELON,%20F.&rft.genre=article |
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