Is the subcutaneous route an alternative for administering ertapenem to older patients? PHACINERTA study
| dc.rights.license | open | en_US |
| dc.contributor.author | ROUBAUD BAUDRON, C. | |
| dc.contributor.author | LEGERON, R. | |
| dc.contributor.author | OLLIVIER, J. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BONNET, Fabrice | |
| dc.contributor.author | GREIB, C. | |
| dc.contributor.author | GUERVILLE, F. | |
| dc.contributor.author | CAZANAVE, C. | |
| dc.contributor.author | KOBEH, D. | |
| dc.contributor.author | CRESSOT, V. | |
| dc.contributor.author | MONEGER, N. | |
| dc.contributor.author | VIDEAU, M. N. | |
| dc.contributor.author | THIEL, E. | |
| dc.contributor.author | FOUCAUD, C. | |
| dc.contributor.author | LAFARGUE, A. | |
| dc.contributor.author | DE THEZY, A. | |
| dc.contributor.author | DURRIEU, J. | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | BOURDEL MARCHASSON, Isabelle | |
| dc.contributor.author | PINGANAUD, G. | |
| dc.contributor.author | BREILH, D. | |
| dc.date.accessioned | 2020-07-10T11:55:27Z | |
| dc.date.available | 2020-07-10T11:55:27Z | |
| dc.date.issued | 2019-12-01 | |
| dc.identifier.issn | 0305-7453 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/10407 | |
| dc.description.abstractEn | BACKGROUND: Antibiotic administration by subcutaneous (SC) injection is common practice in French geriatric wards as an alternative to the intravenous (IV) route, but few pharmacokinetic/pharmacodynamic data are available. Ertapenem is useful for the treatment of infections with ESBL-producing enterobacteria. OBJECTIVES: To report and compare ertapenem pharmacokinetic data between IV and SC routes in older persons. METHODS: Patients >65 years of age receiving ertapenem (1 g once daily) for at least 48 h (IV or SC, steady-state) were prospectively enrolled. Total ertapenem concentrations [residual (C0), IV peak (C0.5) and SC peak (C2.5)] were determined by UV HPLC. Individual-predicted AUC0-24 values were calculated and population pharmacokinetic analyses were performed. Using the final model, a Monte Carlo simulation involving 10 000 patients evaluated the influence of SC or IV administration on the PTA. Tolerance to ertapenem and recovery were also monitored. ClinicalTrials.gov identifier: NCT02505386. RESULTS: Ten (mean +/- SD age=87+/-7 years) and 16 (age=88+/-5 years) patients were included in the IV and SC groups, respectively. The mean C0 and C2.5 values were not significantly different between the IV and SC groups (C0=12+/-5.9 versus 12+/-7.4 mg/L, P=0.97; C2.5=97+/-42 versus 67+/-41 mg/L, P=0.99). The mean C0.5 was higher in the IV group compared with the SC group (C0.5=184+/-90 versus 51+/-66 mg/L, P=0.001). The mean individual AUCs (1126.92+/-334.99 mg.h/L for IV versus 1005.3+/-266.0 mg.h/L for SC, P=0.38) and PTAs were not significantly different between groups. No severe antibiotic-related adverse effects were noted. CONCLUSIONS: SC administration of ertapenem is an alternative to IV administration in older patients. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | MORPH3Eus | |
| dc.title.en | Is the subcutaneous route an alternative for administering ertapenem to older patients? PHACINERTA study | |
| dc.title.alternative | J Antimicrob Chemother | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/jac/dkz385 | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 31730164 | en_US |
| bordeaux.journal | The Journal of antimicrobial chemotherapy | en_US |
| bordeaux.page | 3546-3554 | en_US |
| bordeaux.volume | 74 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 12 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03162359 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-08T13:40:41Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=The%20Journal%20of%20antimicrobial%20chemotherapy&rft.date=2019-12-01&rft.volume=74&rft.issue=12&rft.spage=3546-3554&rft.epage=3546-3554&rft.eissn=0305-7453&rft.issn=0305-7453&rft.au=ROUBAUD%20BAUDRON,%20C.&LEGERON,%20R.&OLLIVIER,%20J.&BONNET,%20Fabrice&GREIB,%20C.&rft.genre=article |
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