Effect of replacing main-chain ureas with thiourea and guanidinium surrogates on the bactericidal activity of membrane active oligourea foldamers
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | ANTUNES, Stephanie | |
| dc.contributor.author | CORRE, Jean-Philippe | |
| dc.contributor.author | MIKATY, Guillain | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | DOUAT, Celine | |
| dc.contributor.author | GOOSSENS, Pierre L. | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | GUICHARD, Gilles
IDREF: 084339268 | |
| dc.date.accessioned | 2020-07-09T14:17:17Z | |
| dc.date.available | 2020-07-09T14:17:17Z | |
| dc.date.issued | 2017-08-15 | |
| dc.identifier.issn | 0968-0896 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/10366 | |
| dc.description.abstractEn | Membrane-active foldamers have recently emerged as potential mimics of antimicrobial peptides (AMPs). Amphiphilic cationic helical N,N'-linked oligoureas are one such class of AMP mimics with activities in vitro against a broad range of bacteria including Bacillus anthracis, a Gram-positive sporulating bacillus and causing agent of anthrax. Here we have used site-selective chemical modifications of the oligourea backbone to gain additional insight into the relationship between structure and function and modulate anthracidal activity. A series of analogues in which urea linkages at selected positions are replaced by thiourea and guanidium surrogates have been prepared on solid support and tested against different bacterial forms of B. anthracis (germinated spores and encapsulated bacilli). Urea ? thiourea and urea? guanidinium replacements close to the negative end of the helix dipole led to analogues with increased potency and selectivity for B. anthracis versus mammalian cells. (C) 2017 Elsevier Ltd. All rights reserved. | |
| dc.title.en | Effect of replacing main-chain ureas with thiourea and guanidinium surrogates on the bactericidal activity of membrane active oligourea foldamers | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1016/j.bmc.2017.04.040 | |
| dc.subject.hal | Chimie/Matériaux | |
| bordeaux.journal | Bioorganic & Medicinal Chemistry | |
| bordeaux.page | 4245-4252 | |
| bordeaux.volume | 25 | |
| bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | * |
| bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248) | |
| bordeaux.issue | 16 | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Bioorganic%20&%20Medicinal%20Chemistry&rft.date=2017-08-15&rft.volume=25&rft.issue=16&rft.spage=4245-4252&rft.epage=4245-4252&rft.eissn=0968-0896&rft.issn=0968-0896&rft.au=ANTUNES,%20Stephanie&CORRE,%20Jean-Philippe&MIKATY,%20Guillain&DOUAT,%20Celine&GOOSSENS,%20Pierre%20L.&rft.genre=article |
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