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N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death
dc.contributor.author | DUFOUR, Florent | |
dc.contributor.author | RATTIER, Thibault | |
dc.contributor.author | SHIRLEY, Sarah | |
dc.contributor.author | PICARDA, Gaelle | |
dc.contributor.author | CONSTANTINESCU, Andrei Alexandru | |
dc.contributor.author | MORLE, Aymeric | |
dc.contributor.author | ZAKARIA, Al Batoul | |
dc.contributor.author | MARCION, Guillaume | |
dc.contributor.author | CAUSSE, Sebastien | |
dc.contributor.author | SZEGEZDI, Eva | |
dc.contributor.author | ZAJONC, Dirk Michael | |
dc.contributor.author | SEIGNEURIC, Renaud | |
hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
dc.contributor.author | GUICHARD, Gilles | |
dc.contributor.author | GHARBI, Tijani | |
dc.contributor.author | PICAUD, Fabien | |
dc.contributor.author | HERLEM, Guillaume | |
dc.contributor.author | GARRIDO, Carmen | |
dc.contributor.author | SCHNEIDER, Pascal | |
dc.contributor.author | BENEDICT, Chris Alan | |
dc.contributor.author | MICHEAU, Olivier | |
dc.date.accessioned | 2020-07-09T14:16:58Z | |
dc.date.available | 2020-07-09T14:16:58Z | |
dc.date.issued | 2017-03 | |
dc.identifier.issn | 1350-9047 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/10330 | |
dc.description.abstractEn | APO2L/TRAIL (TNF-related apoptosis-inducing ligand) induces death of tumor cells through two agonist receptors, TRAIL-R1 and TRAIL-R2. We demonstrate here that N-linked glycosylation (N-glyc) plays also an important regulatory role for TRAIL-R1-mediated and mouse TRAIL receptor (mTRAIL-R)-mediated apoptosis, but not for TRAIL-R2, which is devoid of N-glycans. Cells expressing N-glyc-defective mutants of TRAIL-R1 and mouse TRAIL-R were less sensitive to TRAIL than their wild-type counterparts. Defective apoptotic signaling by N-glyc-deficient TRAIL receptors was associated with lower TRAIL receptor aggregation and reduced DISC formation, but not with reduced TRAIL-binding affinity. Our results also indicate that TRAIL receptor N-glyc impacts immune evasion strategies. The cytomegalovirus (CMV) UL141 protein, which restricts cell-surface expression of human TRAIL death receptors, binds with significant higher affinity TRAIL-R1 lacking N-glyc, suggesting that this sugar modification may have evolved as a counterstrategy to prevent receptor inhibition by UL141. Altogether our findings demonstrate that N-glyc of TRAIL-R1 promotes TRAIL signaling and restricts virus-mediated inhibition. | |
dc.title.en | N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1038/cdd.2016.150 | |
dc.subject.hal | Chimie/Matériaux | |
bordeaux.journal | Cell death and differentiation | |
bordeaux.page | 500-510 | |
bordeaux.volume | 24 | |
bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248 | * |
bordeaux.hal.laboratories | Institut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248) | |
bordeaux.issue | 3 | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | Bordeaux INP | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20death%20and%20differentiation&rft.date=2017-03&rft.volume=24&rft.issue=3&rft.spage=500-510&rft.epage=500-510&rft.eissn=1350-9047&rft.issn=1350-9047&rft.au=DUFOUR,%20Florent&RATTIER,%20Thibault&SHIRLEY,%20Sarah&PICARDA,%20Gaelle&CONSTANTINESCU,%20Andrei%20Alexandru&rft.genre=article |
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