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Metal-Coordination-Assisted Folding and Guest Binding in Helical Aromatic Oligoamide Molecular Capsules

dc.relation.isnodouble8787c50e-c20a-4284-95e8-7807da1c97d8*
dc.relation.isnodoublefa9ceb49-1614-4269-9360-66150af18b13*
dc.relation.isnodoubled3e9affd-c524-4b95-a31c-566d7ca6ec51*
dc.contributor.authorHOREAU, Maxime
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLAUTRETTE, Guillaume
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorWICHER, Barbara
dc.contributor.authorBLOT, Virginie
dc.contributor.authorLEBRETON, Jacques
dc.contributor.authorPIPELIER, Muriel
dc.contributor.authorDUBREUIL, Didier
dc.contributor.authorFERRAND, Yann
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorHUC, Ivan
dc.date.accessioned2020-07-09T14:16:50Z
dc.date.available2020-07-09T14:16:50Z
dc.date.issued2017-06-06
dc.identifier.issn1433-7851
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10313
dc.description.abstractEnThe development of foldamer-based receptors is driven by the design of monomers with specific properties. Herein, we introduce a pyridazine-pyridine-pyridazine diacid monomer and its incorporation into helical aromatic oligoamide foldamer containers. This monomer codes for a wide helix diameter and can sequester metal ions on the inner wall of the helix cavity. Crystallographic studies and NMR titrations show that part of the metal coordination sphere remains available and may then promote the binding of a guest within the cavity. In addition to metal coordination, binding of the guest is assisted by cooperative interactions with the helix host, thereby resulting in significant enhancements depending on the foldamer sequence, and in slow guest capture and release on the NMR time scale. In the absence of metal ions, the pyridazine-pyridine-pyridazine monomer promotes an extended conformation of the foldamer that results in aggregation, including the formation of an intertwined duplex.
dc.title.enMetal-Coordination-Assisted Folding and Guest Binding in Helical Aromatic Oligoamide Molecular Capsules
dc.typeArticle de revue
dc.identifier.doi10.1002/anie.201701693
dc.subject.halChimie/Matériaux
bordeaux.journalAngewandte Chemie-International Edition
bordeaux.page6823-6827
bordeaux.volume56
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.issue24
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
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