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Simultaneous monitoring of single cell and of micro-organ activity by PEDOT:PSS covered multi-electrode arrays

dc.contributor.authorKOUTSOURAS, Dimitrios A.
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorPERRIER, Romain
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorMARQUEZ, Ariana Villarroel
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorPIROG, Antoine
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorPEDRAZA, Eileen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorCLOUTET, Eric
IDREF: 151048681
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorRENAUD, Sylvie
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorRAOUX, Matthieu
dc.contributor.authorMALLIARAS, George G.
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLANG, Jochen
dc.date.accessioned2020-07-09T14:16:47Z
dc.date.available2020-07-09T14:16:47Z
dc.date.issued2017-12-01
dc.identifier.issn0928-4931
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10306
dc.description.abstractEnContinuous and long-term monitoring of cellular and micro-organ activity is required for new insights into physiology and novel technologies such as Organs-on-Chip. Moreover, recent advances in stem cell technology and especially in the field of diabetes call for non-invasive approaches in quality testing of the large quantities of surrogate pancreatic islets to be generated. Electrical activity of such a micro-organ results in single cell action potentials (APs) of high frequency and in low frequency changes in local field potentials (slow potentials or SPs), reflecting coupled cell activity and overall organ physiology. Each of them is indicative of different physiological stages in islet activation. Action potentials in islets are of small amplitude and very difficult to detect. The use of PEDOT:PSS to coat metal electrodes is expected to reduce noise and results in a frequency-dependent change in impedance, as shown here. Whereas detection of high-frequency APs improves, low frequency SPs are less well detected which is, however, an acceptable trade off in view of the strong amplitude of SPs. Using a dedicated software, recorded APs and SPs can be automatically diagnosed and analyzed. Concomitant capture of the two signals will considerably increase the diagnostic power of monitoring islets and islet surrogates in fundamental research as well as drug screening or the use of islets as biosensors.
dc.title.enSimultaneous monitoring of single cell and of micro-organ activity by PEDOT:PSS covered multi-electrode arrays
dc.typeArticle de revue
dc.identifier.doi10.1016/j.msec.2017.07.028
dc.subject.halChimie/Matériaux
bordeaux.journalMaterials science & engineering C-Materials for biological applications
bordeaux.page84-89
bordeaux.volume81
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Materials%20science%20&%20engineering%20C-Materials%20for%20biological%20applications&rft.date=2017-12-01&rft.volume=81&rft.spage=84-89&rft.epage=84-89&rft.eissn=0928-4931&rft.issn=0928-4931&rft.au=KOUTSOURAS,%20Dimitrios%20A.&PERRIER,%20Romain&MARQUEZ,%20Ariana%20Villarroel&PIROG,%20Antoine&PEDRAZA,%20Eileen&rft.genre=article


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