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Pathways of Association Between Childhood Irritability and Adolescent Suicidality

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorORRI, Massimiliano
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGALERA, Cedric
dc.contributor.authorTURECKI, Gustavo
dc.contributor.authorBOIVIN, Michel
dc.contributor.authorTREMBLAY, Richard
dc.contributor.authorGEOFFROY, Marie-Claude
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOTE, Sylvana
dc.date.accessioned2020-07-09T12:49:01Z
dc.date.available2020-07-09T12:49:01Z
dc.date.issued2019-01
dc.identifier.issn0890-8567en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10274
dc.description.abstractEnOBJECTIVE: Childhood irritability predicts suicidal ideation/attempt (suicidality), but it is unclear whether irritability is an independent and direct risk factor for suicidality or a marker of intermediate mental health symptoms associated with suicidality. This study aimed to identify developmental patterns of childhood irritability and to test whether childhood irritability is directly associated with suicidality or indirectly associated with intermediate mental health symptoms. METHOD: One thousand three hundred ninety-three participants from the Quebec Longitudinal Study of Child Development were followed from birth to 17 years. Teachers assessed irritability yearly (at 6-12 years) and children self-reported intermediate mental health symptoms (depression, anxiety, disruptiveness, and hyperactivity-impulsivity; at 13 years) and suicidality (at 15 and 17 years). RESULTS: Four irritability trajectories were identified: low (74.7%), rising (13.0%), declining (7.4%), and persistent (5.0%). Children following a rising irritability trajectory (versus a low trajectory) were at higher suicidality risk. A large proportion of this association was direct (odds ratio 2.11, 95% CI 1.30-3.43) and a small proportion was indirect by depressive symptoms (accounting for 23% of the association; odds ratio 1.17, 95% CI 1.03-1.34). Children on a persistent irritability trajectory (versus a low trajectory) were at higher risk of suicidality and this association was uniquely indirect by depressive symptoms (accounting for 73% of the association; odds ratio 1.51, 95% CI 1.16-1.97). The declining trajectory was not related to suicidality; no association with anxiety, disruptiveness, and hyperactivity-impulsivity was found. CONCLUSION: Rising irritability across childhood represents a direct risk for suicidality. Persistent irritability appears to be a distal marker of suicidality acting through more proximal depressive symptoms.
dc.language.isoENen_US
dc.subject.enHEALTHY
dc.title.enPathways of Association Between Childhood Irritability and Adolescent Suicidality
dc.title.alternativeJ Am Acad Child Adolesc Psychiatryen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jaac.2018.06.034en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30661490en_US
bordeaux.journalJournal of the American Academy of Child and Adolescent Psychiatryen_US
bordeaux.page99-107.e3en_US
bordeaux.volume58en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamHEALTHY_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-02895132
hal.version1
hal.date.transferred2020-07-09T12:49:05Z
hal.exporttrue
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