Pharmacists' role in antimicrobial stewardship and relationship with antibiotic consumption in hospitals: An observational multicentre study
| dc.rights.license | open | en_US |
| dc.contributor.author | OURGHANLIAN, C. | |
| dc.contributor.author | LAPIDUS, N. | |
| dc.contributor.author | ANTIGNAC, M. | |
| dc.contributor.author | FERNANDEZ, C. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DUMARTIN, Catherine | |
| dc.contributor.author | HINDLET, P. | |
| dc.date.accessioned | 2020-07-09T09:02:43Z | |
| dc.date.available | 2020-07-09T09:02:43Z | |
| dc.date.issued | 2019-07-16 | |
| dc.identifier.issn | 2213-7173 (Electronic) 2213-7165 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/10261 | |
| dc.description.abstractEn | OBJECTIVES: Worldwide, antimicrobial stewardship (AMS) teams include pharmacists, but their impact is little known. This study aimed to explore the relationship between pharmacists' actions and antibiotic consumption. METHODS: Hospital pharmacists involved in the French antibiotic consumption surveillance network (ATB-Raisin) were invited to participate in a retrospective observational multicentre study. Collected data were: the previous year's (2016) antibiotic consumption expressed in Daily Defined Dose per 1.000 Patient-Days, AMS measures, including pharmacist-specific actions and use of a computerized prescription order entry (CPOE) system. Associations between antibiotic consumption and AMS measures were assessed by linear regression, after adjustment for hospital activities. RESULTS: Annual data for 2016 from 77 hospitals (7,260,000 bed-days in 24,000 beds) were analysed. Pharmacists were involved in AMS programs in 73% of hospitals, and were the antibiotic advisor in 25%. Pharmaceutical review of prescriptions was organized in almost all hospitals (97%). The univariable analysis identified five measures associated with lower overall antibiotic consumption: CPOE use (if >80% of prescriptions; or 100%), pharmaceutical review (if >80% of beds; or 100%), and the antibiotic advisor being a pharmacist (p = 0.04, 0.004 and 0.003, respectively). In the multivariable analysis, two explanatory variables were significantly, independently associated with a lower overall antibiotic consumption: antibiotic advisor being a pharmacist and pharmaceutical review covering all beds (- 19.9% [-31.6%; -8.1%], p = 0.002 and - 18.3% [-34.0%; -2.6%], p = 0.03, respectively). CONCLUSIONS: Antibiotic consumption was lower when the antibiotic advisor was a pharmacist and when the pharmaceutical team reviewed all prescriptions. These results highlight that actions initiated by pharmacists have a positive impact and should be supported. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Unported | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ | |
| dc.subject.en | PharmacoEpi-Drugs | |
| dc.title.en | Pharmacists' role in antimicrobial stewardship and relationship with antibiotic consumption in hospitals: An observational multicentre study | |
| dc.title.alternative | J Glob Antimicrob Resist | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.jgar.2019.07.009 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 31323427 | en_US |
| bordeaux.journal | Journal of global antimicrobial resistance | en_US |
| bordeaux.page | 131-134 | en_US |
| bordeaux.volume | 20 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
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