Depression Increases the Risk of Death Independently From Vascular Events in Elderly Individuals: The Three-City Study
| dc.rights.license | open | en_US |
| dc.contributor.author | PEQUIGNOT, R. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DUFOUIL, Carole | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PERES, Karine | |
| dc.contributor.author | ARTERO, S. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | TZOURIO, Christophe | |
| dc.contributor.author | EMPANA, J. P. | |
| dc.date.accessioned | 2020-07-09T08:35:59Z | |
| dc.date.available | 2020-07-09T08:35:59Z | |
| dc.date.issued | 2019-03 | |
| dc.identifier.issn | 1532-5415 (Electronic) 0002-8614 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/10252 | |
| dc.description.abstractEn | BACKGROUND: How much the association between depressive symptoms (DSs) and all-cause mortality depends on cardiovascular disease (CVD) events is poorly known. We aimed to prospectively quantify the association between DSs at repeated study visits and all-cause and cause-specific mortality, and the influence of incident CVD on this association. METHODS: The Three-City Study has included adults 65 years and older, who were examined at baseline between 1999 and 2001 and after 2, 4, 7, and 10 years of follow-up. At each visit, a score of 16 or greater on the 20-item Center for Epidemiologic Studies Depression Scale defined the presence of DSs. DS status and incident coronary heart disease or stroke events were used as time-dependent variables in a Cox proportional hazard model of mortality. RESULTS: We studied 7377 participants (63.7% females) aged 73.8 years (SD = 5.4 years) without a history of CVD at baseline examination. DSs were present in 19% to 22% of subjects at each study visit. During a median follow-up of 9.4 years, 650 subjects developed a first CVD, and 1255 had died. After adjustment for baseline sociodemographic variables, vascular risk factors, impairment in daily life activities, and antidepressants, time-dependent DSs were associated with a 28% increased risk of mortality (hazard ratio [HR] = 1.28; 95% confidence interval [CI] = 1.06-1.55), and incident CVD event was associated with a 63% increased risk (HR = 1.63; 95% CI = 1.30-2.04). However, the association between DSs and mortality was not influenced by the occurrence of CVD (HR for DS and CVD interaction = 1.03; 95% CI = 0.66-1.61). A mediation analysis confirmed that incident CVD only explained 6.9% of the excess of mortality associated with DSs. CONCLUSION: In older participants, the increased risk of all-cause mortality associated with the presence of DSs at baseline and during follow-up is not modified by and is moderately mediated by incident CVD. J Am Geriatr Soc 00:1-7, 2019. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | HEALTHY | |
| dc.subject.en | SEPIA | |
| dc.subject.en | FR | |
| dc.subject.en | VINTAGE | |
| dc.title.en | Depression Increases the Risk of Death Independently From Vascular Events in Elderly Individuals: The Three-City Study | |
| dc.title.alternative | J Am Geriatr Soc | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/jgs.15731 | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 30652829 | en_US |
| bordeaux.journal | Journal of the American Geriatrics Society | en_US |
| bordeaux.page | 546-552 | en_US |
| bordeaux.volume | 67 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.issue | 3 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | HEALTHY_BPH | |
| bordeaux.team | VINTAGE | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.date.transferred | 2021-03-12T10:39:09Z | |
| hal.export | false | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20the%20American%20Geriatrics%20Society&rft.date=2019-03&rft.volume=67&rft.issue=3&rft.spage=546-552&rft.epage=546-552&rft.eissn=1532-5415%20(Electronic)%200002-8614%20(Linking)&rft.issn=1532-5415%20(Electronic)%200002-8614%20(Linking)&rft.au=PEQUIGNOT,%20R.&DUFOUIL,%20Carole&PERES,%20Karine&ARTERO,%20S.&TZOURIO,%20Christophe&rft.genre=article |
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