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High Activation of gammadelta T Cells and the gammadelta2(pos) T-Cell Subset Is Associated With the Onset of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome, ANRS 12153 CAPRI NK

dc.rights.licenseopenen_US
dc.contributor.authorPEAN, P.
dc.contributor.authorNOUHIN, J.
dc.contributor.authorRATANA, M.
dc.contributor.authorMADEC, Y.
dc.contributor.authorBORAND, L.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMARCY, Olivier
dc.contributor.authorLAUREILLARD, D.
dc.contributor.authorFERNANDEZ, M.
dc.contributor.authorBARRE-SINOUSSI, F.
dc.contributor.authorWEISS, L.
dc.contributor.authorSCOTT-ALGARA, D.
dc.date.accessioned2020-07-09T08:26:35Z
dc.date.available2020-07-09T08:26:35Z
dc.date.issued2019-08-27
dc.identifier.issn1664-3224en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10249
dc.description.abstractEnBackground: Human Immunodeficiency Virus 1 (HIV-1) and Mycobacterium Tuberculosis (Mtb) co-infected patients are commonly at risk of immune reconstitution inflammatory syndrome (IRIS) when initiating antiretroviral treatment (ART). Evidence indicates that innate immunity plays a role in TB-IRIS. Here, we evaluate the phenotype of Gamma-delta (gammadelta) T cells and invariant Natural Killer (iNK) T cells in tuberculosis-associated IRIS. Methods: Forty-eight HIV+/TB+ patients (21 IRIS) and three control groups: HIV-/TB- (HD, n = 11), HIV+/TB- (n = 26), and HIV-/TB+ (n = 22) were studied. Samples were taken at ART initiation (week 2 of anti-tuberculosis treatment) and at the diagnosis of IRIS for HIV+/TB+; before ART for HIV+/TB-, and at week 2 of anti-tuberculosis treatment for HIV-/TB+ patients. gammadelta T cells and Invariant natural killer T (iNKT) cells were analyzed by flow cytometry. Results: Before ART, IRIS, and non-IRIS patients showed a similar proportion of gammadelta(pos) T and iNKT cells. HLA-DR on gammadelta(pos) T cells and delta2(pos)gammadelta(pos) T cells was significantly higher in TB-IRIS vs. non-IRIS patients and controls (p < 0.0001). NKG2D expression on gammadelta(pos) T cells and the delta2(pos)gammadelta(pos) T cell subset was lower in HIV+/TB+ patients than controls. CD158a expression on gammadelta(pos) T cells was higher in TB-IRIS than non-IRIS (p = 0.02), HIV+/TB-, and HIV-/TB- patients. Conclusion: The higher activation of gammadelta(pos)T cells and the gammadelta2(pos)gammadelta(pos) T cell subset suggests that gammadelta T cells may play a role in the pathogenesis of TB-IRIS.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/us/
dc.subject.enIDLIC
dc.title.enHigh Activation of gammadelta T Cells and the gammadelta2(pos) T-Cell Subset Is Associated With the Onset of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome, ANRS 12153 CAPRI NK
dc.title.alternativeFront Immunolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3389/fimmu.2019.02018en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31507608en_US
bordeaux.journalFrontiers in immunologyen_US
bordeaux.page2018en_US
bordeaux.volume10en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Viralesen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Frontiers%20in%20immunology&amp;rft.date=2019-08-27&amp;rft.volume=10&amp;rft.spage=2018&amp;rft.epage=2018&amp;rft.eissn=1664-3224&amp;rft.issn=1664-3224&amp;rft.au=PEAN,%20P.&amp;NOUHIN,%20J.&amp;RATANA,%20M.&amp;MADEC,%20Y.&amp;BORAND,%20L.&amp;rft.genre=article


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