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The salivary proteome reflects some traits of dietary habits in diabetic and non-diabetic older adults

dc.rights.licenseopenen_US
dc.contributor.authorCHAMBON, Christophe
dc.contributor.authorNEYRAUD, Eric
dc.contributor.authorSAYD, Thierry
dc.contributor.authorBROS, Pauline
dc.contributor.authorDI BIAGIO, Romane
dc.contributor.authorHYVRIER, Frank
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFEART-COURET, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorANDRE, Perrine
dc.contributor.authorRODRIGUEZ-ARTALEJO, Fernando
dc.contributor.authorLOPEZ-GARCIA, Esther
dc.contributor.authorGARCIA-ESQUINAS, Esther
dc.contributor.authorGOMEZ-CABRERO, David
dc.contributor.authorPROCTOR, Gordon
dc.contributor.authorMORZEL, Martine
dc.date.accessioned2021-07-05T10:06:00Z
dc.date.available2021-07-05T10:06:00Z
dc.date.issued2021-05-26
dc.identifier.issn1436-6207en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/94974
dc.description.abstractEnPURPOSE: Objective markers of usual diet are of interest as alternative or validating tools in nutritional epidemiology research. The main purpose of the work was to assess whether saliva protein composition can reflect dietary habits in older adults, and how type 2 diabetes impacted on the saliva-diet correlates. METHODS: 214 participants were selected from 2 European cohorts of community-dwelling older adults (3C-Bordeaux and Seniors-ENRICA-2), using a case-control design nested in each cohort. Cases were individuals with type 2 diabetes. Dietary information was obtained using the Mediterranean Diet Adherence Screener (MEDAS). Saliva was successfully obtained from 211 subjects, and its proteome analyzed by liquid chromatography-tandem mass spectrometry. RESULTS: The relative abundance of 246 saliva proteins was obtained across all participants. The salivary proteome differed depending on the intake level of some food groups (especially vegetables, fruits, sweet snacks and red meat), in a diabetic status- and cohort-specific manner. Gene Set Enrichment Analysis suggested that some biological processes were consistently affected by diet across cohorts, for example enhanced platelet degranulation in high consumers of sweet snacks. Minimal models were then fitted to predict dietary variables by sociodemographic, clinical and salivary proteome variables. For the food group «sweet snacks», selected salivary proteins contributed to the predictive model and improved its performance in the Seniors-ENRICA-2 cohort and when both cohorts were combined. CONCLUSION: Saliva proteome composition of elderly individuals can reflect some aspects of dietary patterns.
dc.language.isoENen_US
dc.subject.enSalivary biomarkers
dc.subject.enProteomics
dc.subject.enUsual diet
dc.subject.enAgeing
dc.subject.enDiabetes
dc.subject.enGene Set Enrichment Analysis
dc.title.enThe salivary proteome reflects some traits of dietary habits in diabetic and non-diabetic older adults
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00394-021-02584-2en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34041584en_US
bordeaux.journalEuropean Journal of Nutritionen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDBiotechnology and Biological Sciences Research Councilen_US
hal.exportfalse
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