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dc.rights.licenseopenen_US
dc.contributor.authorVAN DE PERRE, Philippe
dc.contributor.authorGOGA, Ameena
dc.contributor.authorNGANDU, Nobubelo
dc.contributor.authorNAGOT, Nicolas
dc.contributor.authorMOODLEY, Dhayendre
dc.contributor.authorKING, Rachel
dc.contributor.authorMOLES, Jean-Pierre
dc.contributor.authorMOSQUEIRA, Beatriz
dc.contributor.authorCHIRINDA, Witness
dc.contributor.authorSCARLATTI, Gabriella
dc.contributor.authorTYLLESKAR, Thorkild
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDABIS, Francois
dc.contributor.authorGRAY, Glenda
dc.date.accessioned2021-06-30T10:14:53Z
dc.date.available2021-06-30T10:14:53Z
dc.date.issued2021-04-03
dc.identifier.issn0140-6736en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/94938
dc.description.abstractEnThe rate of mother-to-child transmission (MTCT) of HIV from breastfeeding is increasing relative to other causes of MTCT. Early effective preconception and antenatal antiretroviral therapy (ART) reduces intrauterine and intrapartum MTCT, whereas maternal post-partum HIV acquisition, untreated maternal HIV, and suboptimal postnatal maternal ART adherence increase the risk of MTCT through breastfeeding. Although the absolute number of cases of MTCT acquired through breastfeeding is decreasing, the rate of decrease is less than the decrease in intrauterine and intrapartum MTCT. Unless current strategies are universally applied, they might not be sufficient to eliminate MTCT due to breastfeeding. Urgent action is needed to evaluate and implement additional preventive biomedical strategies in high HIV prevalence and incidence settings to eliminate MTCT from breastfeeding. Preventive strategies include: pre-exposure prophylaxis in breastfeeding women who have an increased risk of acquiring HIV; postnatal reinforcement strategies, such as maternal retesting for HIV, maternal care reinforcement, and prophylaxis in infants exposed to HIV via breastmilk; and active (vaccine) or passive immunoprophylaxis with long-acting broadly neutralising antibodies.
dc.language.isoENen_US
dc.title.enEliminating postnatal HIV transmission in high incidence areas: need for complementary biomedical interventions
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/s0140-6736(21)00570-5en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.journalLanceten_US
bordeaux.page1316-1324en_US
bordeaux.volume397en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue10281en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamIDLICen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03274638
hal.version1
hal.date.transferred2021-06-30T10:14:57Z
hal.exporttrue
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