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Increased risk of central nervous system tumours with carbamate insecticide use in the prospective cohort AGRICAN

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPIEL, Clement
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPOUCHIEU, Camille
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMIGAULT, Lucile
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBEZIAT, Beatrix
dc.contributor.authorBOULANGER, Mathilde
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBUREAU, Mathilde
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCARLES, Camille
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGRUBER, Anne
dc.contributor.authorLECLUSE, Yannick
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRONDEAU, Virginie
ORCID: 0000-0001-7109-4831
IDREF: 16662988X
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSCHWALL, Xavier
dc.contributor.authorTUAL, Severine
dc.contributor.authorLEBAILLY, Pierre
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBALDI, Isabelle
dc.date.accessioned2020-07-03T13:56:05Z
dc.date.available2020-07-03T13:56:05Z
dc.date.issued2019-11-23
dc.identifier.issn1464-3685 (Electronic) 0300-5771 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8572
dc.description.abstractEnBackground: Pesticide exposures are suspected to be implicated in the excess of central nervous system (CNS) tumours observed in farmers, but evidence concerning individual pesticides remains limited. Carbamate insecticides, used on a wide range of crops, have shown evidence of carcinogenicity in some experimental studies. In the cohort AGRICAN (AGRIculture & CANcer), we assessed the associations between potential exposures to carbamate insecticides and the incidence of CNS tumours, overall and by histological subtype. Methods: AGRICAN enrolled 181 842 participants involved in agriculture. Incident CNS tumours were identified by linkage with cancer registries from enrolment (2005-07) until 2013. Carbamate exposure was assessed by combining information on lifetime periods of pesticide use on crop or livestock and the French crop-exposure matrix PESTIMAT, individually for each of the 19 carbamate insecticides registered in France since 1950. Associations were estimated using proportional hazards models with age as the underlying time scale, adjusting for gender, educational level and smoking. Results: During a 6.9-year average follow-up, 381 incident cases of CNS tumours occurred, including 164 gliomas and 134 meningiomas. Analyses showed increased risks of CNS tumours with overall exposure to carbamate insecticides and linear trends with duration of use of each carbamate. Considering tumour subtypes, hazard ratios for gliomas ranged from 1.18 for thiofanox to 4.60 for formetanate, and for meningiomas from 1.51 for carbaryl to 3.67 for thiofanox. Conclusions: Findings reinforce carcinogenicity evidence for already suspected active ingredients and draw attention to additional active ingredients, notably used on fruit trees, vineyards, potatoes and beets.
dc.language.isoENen_US
dc.subject.enBiostatistics
dc.subject.enEPICENE
dc.title.enIncreased risk of central nervous system tumours with carbamate insecticide use in the prospective cohort AGRICAN
dc.title.alternativeInt J Epidemiolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ije/dyy246en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30476073en_US
bordeaux.journalInternational journal of epidemiologyen_US
bordeaux.page512-526en_US
bordeaux.volume48en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamEPICENE_BPH
bordeaux.teamBIOSTAT_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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