Sex-specific depressive symptoms as markers of pre-Alzheimer dementia: findings from the Three-City cohort study
| dc.rights.license | open | en_US |
| dc.contributor.author | NORTON, J. | |
| dc.contributor.author | CARRIERE, I. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PERES, Karine
ORCID: 0000-0002-0720-0684 IDREF: 080634001 | |
| dc.contributor.author | GABELLE, A. | |
| dc.contributor.author | BERR, C. | |
| dc.contributor.author | RITCHIE, K. | |
| dc.contributor.author | ANCELIN, M. L. | |
| dc.date.accessioned | 2020-07-01T10:13:06Z | |
| dc.date.available | 2020-07-01T10:13:06Z | |
| dc.date.issued | 2019-11-11 | |
| dc.identifier.issn | 2158-3188 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/8392 | |
| dc.description.abstractEn | Late-life depression, as a potential marker of pre-dementia, has seldom been explored by symptom dimension and sex, despite sexual dimorphic differences. This study aimed to examine whether specific depressive dimensions were associated with pre-Alzheimer's disease dementia (pre-AD), separately for women and men. Data were drawn from 5617 (58% women) community-dwellers aged 65+ recruited in 1999-2000 and followed at 2-year intervals for 12 years. We used Cox proportional hazard models to study associations between time-dependent Centre for Epidemiologic Studies-Depression Scale (CES-D) symptom dimensions (namely somatic, depressed, positive affect, and interpersonal challenge) and pre-AD, defined retrospectively from validated diagnoses established 3.5 (IQR: 3.2-4.0) years onwards. Analyses were performed according to overall depressive symptomatology (DS+: CES-D score >/= 16) and antidepressant/anxiolytic medication use (AA). Results indicated that in DS+ women only, all four dimensions were significantly associated with pre-AD in the AA- group, in particular somatic item 'Mind' and depressed affect items 'Depressed' and 'Blues'. The most depression-specific dimension, depressed affect, was also significantly associated with pre-AD in the DS- AA- women (HR:1.28, 95%CI: 1.12;1.47). In both sexes, in the DS- groups somatic affect was the most robust pre-AD marker, irrespective of treatment (women: HR = 1.22, 95%CI: 1.08;1.38; men: HR = 1.30, 95%CI: 1.14;1.48). Our findings highlight sex-specific associations between depressive symptom dimensions and pre-AD, modulated by depressive symptomatology and treatment. Assessment of specific symptom dimensions taking into account overall symptomatology and treatment could help identify and target high-risk AD-dementia profiles for interventions. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | SEPIA | |
| dc.title.en | Sex-specific depressive symptoms as markers of pre-Alzheimer dementia: findings from the Three-City cohort study | |
| dc.title.alternative | Transl Psychiatry | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41398-019-0620-5 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 31712553 | en_US |
| bordeaux.journal | Translational psychiatry | en_US |
| bordeaux.page | 291 | en_US |
| bordeaux.volume | 9 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Translational%20psychiatry&rft.date=2019-11-11&rft.volume=9&rft.issue=1&rft.spage=291&rft.epage=291&rft.eissn=2158-3188&rft.issn=2158-3188&rft.au=NORTON,%20J.&CARRIERE,%20I.&PERES,%20Karine&GABELLE,%20A.&BERR,%20C.&rft.genre=article |
