Long-term outcome of diarrhea-associated hemolytic uremic syndrome is poorly related to markers of kidney injury at 1-year follow-up in a population-based cohort
| dc.rights.license | open | en_US |
| dc.contributor.author | MONET-DIDAILLER, C. | |
| dc.contributor.author | GODRON-DUBRASQUET, A. | |
| dc.contributor.author | MADDEN, I. | |
| dc.contributor.author | DELMAS, Y. | |
| dc.contributor.author | LLANAS, B. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HARAMBAT, Jerome
IDREF: 110567358 | |
| dc.date.accessioned | 2020-07-01T09:32:38Z | |
| dc.date.available | 2020-07-01T09:32:38Z | |
| dc.date.issued | 2019-04 | |
| dc.identifier.issn | 1432-198X (Electronic) 0931-041X (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/8385 | |
| dc.description.abstractEn | BACKGROUND: Hemolytic uremic syndrome due to Shiga toxin-producing E. coli (STEC-HUS) is the main cause of acute kidney injury in young children. Most fully recover kidney function; however, some develop long-term sequelae. We aimed to determine whether kidney injury 1 year after HUS onset is associated with long-term kidney outcome in pediatric STEC-HUS. METHODS: A retrospective population-based study of children < 15 years with STEC-HUS between 1992 and 2012 was performed. Mixed effects logistic regression was used to investigate associations between kidney injury at 1 year and long-term kidney outcome. RESULTS: Ninety-eight STEC-HUS cases were reported. Of 96 patients who survived acute phase, 84 were evaluated at 1-year follow-up of whom 42 (44% of survivors) showed >/= 1 signs of kidney injury. Data from 81 patients were collected after median follow-up of 8.7 (IQR 3.5-12.7) years. At last follow-up, 42 (44% of survivors) had >/= 1 signs of kidney injury including decreased estimated glomerular filtration rate (eGFR) < 90 mL/min/1.73 m(2) (n = 30), proteinuria (n = 17), or hypertension (n = 5). Among 42 patients with kidney injuries at 1-year follow-up, only 22 (52%) still had kidney disease at last follow-up. Conversely, of 33 patients without kidney injury at 1-year and available long-term outcome data, 11 (33%) had proteinuria or decreased GFR at last follow-up. There was no statistically significant association between kidney injury at 1 year and long-term kidney outcome. CONCLUSIONS: Since kidney sequelae may appear at variable time intervals after acute HUS, all patients need lifelong follow-up to detect early signs of chronic kidney disease and propose measures to slow progression. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | LEHA | |
| dc.title.en | Long-term outcome of diarrhea-associated hemolytic uremic syndrome is poorly related to markers of kidney injury at 1-year follow-up in a population-based cohort | |
| dc.title.alternative | Pediatr Nephrol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1007/s00467-018-4131-z | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 30368614 | en_US |
| bordeaux.journal | Pediatric Nephrology | en_US |
| bordeaux.page | 657-662 | en_US |
| bordeaux.volume | 34 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | LEHA_BPH | |
| bordeaux.team | LEHA_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03162451 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-08T14:05:22Z | |
| hal.export | true | |
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