Multiple System Atrophy: Recent Developments and Future Perspectives
| dc.rights.license | open | en_US |
| dc.contributor.author | MEISSNER, W. G. | |
| dc.contributor.author | FERNAGUT, P. O. | |
| dc.contributor.author | DEHAY, B. | |
| dc.contributor.author | PERAN, P. | |
| dc.contributor.author | TRAON, A. P. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | FOUBERT-SAMIER, Alexandra | |
| dc.contributor.author | LOPEZ CUINA, M. | |
| dc.contributor.author | BEZARD, E. | |
| dc.contributor.author | TISON, F. | |
| dc.contributor.author | RASCOL, O. | |
| dc.date.accessioned | 2020-07-01T07:29:35Z | |
| dc.date.available | 2020-07-01T07:29:35Z | |
| dc.date.issued | 2019-11 | |
| dc.identifier.issn | 1531-8257 (Electronic) 0885-3185 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/8352 | |
| dc.description.abstractEn | Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder characterized by a variable combination of parkinsonism, cerebellar impairment, and autonomic dysfunction. The pathologic hallmark is the accumulation of aggregated alpha-synuclein in oligodendrocytes, forming glial cytoplasmic inclusions, which qualifies MSA as a synucleinopathy together with Parkinson's disease and dementia with Lewy bodies. The underlying pathogenesis is still not well understood. Some symptomatic treatments are available, whereas neuroprotection remains an urgent unmet treatment need. In this review, we critically appraise significant developments of the past decade with emphasis on pathogenesis, diagnosis, prognosis, and treatment development. We further discuss unsolved questions and highlight some perspectives. (c) 2019 International Parkinson and Movement Disorder Society. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | SEPIA | |
| dc.title.en | Multiple System Atrophy: Recent Developments and Future Perspectives | |
| dc.title.alternative | Mov Disord | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/mds.27894 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 31692132 | en_US |
| bordeaux.journal | Movement disorders | en_US |
| bordeaux.page | 1629-1642 | en_US |
| bordeaux.volume | 34 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 11 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Movement%20disorders&rft.date=2019-11&rft.volume=34&rft.issue=11&rft.spage=1629-1642&rft.epage=1629-1642&rft.eissn=1531-8257%20(Electronic)%200885-3185%20(Linking)&rft.issn=1531-8257%20(Electronic)%200885-3185%20(Linking)&rft.au=MEISSNER,%20W.%20G.&FERNAGUT,%20P.%20O.&DEHAY,%20B.&PERAN,%20P.&TRAON,%20A.%20P.&rft.genre=article |
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