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Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality

dc.rights.licenseopenen_US
dc.contributor.authorMARKLUND, M.
dc.contributor.authorWU, J. H. Y.
dc.contributor.authorIMAMURA, F.
dc.contributor.authorDEL GOBBO, L. C.
dc.contributor.authorFRETTS, A.
dc.contributor.authorDE GOEDE, J.
dc.contributor.authorSHI, P.
dc.contributor.authorTINTLE, N.
dc.contributor.authorWENNBERG, M.
dc.contributor.authorASLIBEKYAN, S.
dc.contributor.authorCHEN, T. A.
dc.contributor.authorDE OLIVEIRA OTTO, M. C.
dc.contributor.authorHIRAKAWA, Y.
dc.contributor.authorERIKSEN, H. H.
dc.contributor.authorKROGER, J.
dc.contributor.authorLAGUZZI, F.
dc.contributor.authorLANKINEN, M.
dc.contributor.authorMURPHY, R. A.
dc.contributor.authorPREM, K.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.contributor.authorVIRTANEN, J.
dc.contributor.authorWOOD, A. C.
dc.contributor.authorWONG, K.
dc.contributor.authorYANG, W. S.
dc.contributor.authorZHOU, X.
dc.contributor.authorBAYLIN, A.
dc.contributor.authorBOER, J. M. A.
dc.contributor.authorBROUWER, I. A.
dc.contributor.authorCAMPOS, H.
dc.contributor.authorCHAVES, P. H. M.
dc.contributor.authorCHIEN, K. L.
dc.contributor.authorDE FAIRE, U.
dc.contributor.authorDJOUSSE, L.
dc.contributor.authorEIRIKSDOTTIR, G.
dc.contributor.authorEL-ABBADI, N.
dc.contributor.authorFOROUHI, N. G.
dc.contributor.authorMICHAEL GAZIANO, J.
dc.contributor.authorGELEIJNSE, J. M.
dc.contributor.authorGIGANTE, B.
dc.contributor.authorGILES, G.
dc.contributor.authorGUALLAR, E.
dc.contributor.authorGUDNASON, V.
dc.contributor.authorHARRIS, T.
dc.contributor.authorHARRIS, W. S.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorHELLENIUS, M. L.
dc.contributor.authorHODGE, A.
dc.contributor.authorHU, F. B.
dc.contributor.authorJACQUES, P. F.
dc.contributor.authorJANSSON, J. H.
dc.contributor.authorKALSBEEK, A.
dc.contributor.authorKHAW, K. T.
dc.contributor.authorKOH, W. P.
dc.contributor.authorLAAKSO, M.
dc.contributor.authorLEANDER, K.
dc.contributor.authorLIN, H. J.
dc.contributor.authorLIND, L.
dc.contributor.authorLUBEN, R.
dc.contributor.authorLUO, J.
dc.contributor.authorMCKNIGHT, B.
dc.contributor.authorMURSU, J.
dc.contributor.authorNINOMIYA, T.
dc.contributor.authorOVERVAD, K.
dc.contributor.authorPSATY, B. M.
dc.contributor.authorRIMM, E.
dc.contributor.authorSCHULZE, M. B.
dc.contributor.authorSISCOVICK, D.
dc.contributor.authorSKJELBO NIELSEN, M.
dc.contributor.authorSMITH, A. V.
dc.contributor.authorSTEFFEN, B. T.
dc.contributor.authorSTEFFEN, L.
dc.contributor.authorSUN, Q.
dc.contributor.authorSUNDSTROM, J.
dc.contributor.authorTSAI, M. Y.
dc.contributor.authorTUNSTALL-PEDOE, H.
dc.contributor.authorUUSITUPA, M. I. J.
dc.contributor.authorVAN DAM, R. M.
dc.contributor.authorVEENSTRA, J.
dc.contributor.authorMONIQUE VERSCHUREN, W. M.
dc.contributor.authorWAREHAM, N.
dc.contributor.authorWILLETT, W.
dc.contributor.authorWOODWARD, M.
dc.contributor.authorYUAN, J. M.
dc.contributor.authorMICHA, R.
dc.contributor.authorLEMAITRE, R. N.
dc.contributor.authorMOZAFFARIAN, D.
dc.contributor.authorCOHORTS FOR, Heart
dc.contributor.authorAGING RESEARCH IN GENOMIC EPIDEMIOLOGY FATTY, Acids
dc.contributor.authorOUTCOMES RESEARCH, Consortium
dc.date.accessioned2020-06-29T09:54:58Z
dc.date.available2020-06-29T09:54:58Z
dc.date.issued2019-05-21
dc.identifier.issn1524-4539 (Electronic) 0009-7322 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8264
dc.description.abstractEnBACKGROUND: Global dietary recommendations for and cardiovascular effects of linoleic acid, the major dietary omega-6 fatty acid, and its major metabolite, arachidonic acid, remain controversial. To address this uncertainty and inform international recommendations, we evaluated how in vivo circulating and tissue levels of linoleic acid (LA) and arachidonic acid (AA) relate to incident cardiovascular disease (CVD) across multiple international studies. METHODS: We performed harmonized, de novo, individual-level analyses in a global consortium of 30 prospective observational studies from 13 countries. Multivariable-adjusted associations of circulating and adipose tissue LA and AA biomarkers with incident total CVD and subtypes (coronary heart disease (CHD), ischemic stroke, cardiovascular mortality) were investigated according to a prespecified analytical plan. Levels of LA and AA, measured as % of total fatty acids, were evaluated linearly according to their interquintile range (i.e., the range between the mid-point of the first and fifth quintiles), and categorically by quintiles. Study-specific results were pooled using inverse-variance weighted meta-analysis. Heterogeneity was explored by age, sex, race, diabetes, statin use, aspirin use, omega-3 levels, and fatty acid desaturase 1 genotype (when available). RESULTS: In 30 prospective studies with medians of follow-up ranging 2.5 to 31.9 years, 15,198 incident cardiovascular events occurred among 68,659 participants. Higher levels of LA were significantly associated with lower risks of total CVD, cardiovascular mortality, and ischemic stroke, with hazard ratios per interquintile range of 0.93 (95% CI: 0.88-0.99), 0.78 (0.70-0.85), and 0.88 (0.79-0.98), respectively, and nonsignificantly with lower CHD risk (0.94; 0.88-1.00). Relationships were similar for LA evaluated across quintiles. AA levels were not associated with higher risk of cardiovascular outcomes; comparing extreme quintiles, higher levels were associated with lower risk of total CVD (0.92; 0.86-0.99). No consistent heterogeneity by population subgroups was identified in the observed relationships. CONCLUSIONS: In pooled global analyses, higher in vivo circulating and tissue levels of LA and possibly AA were associated with lower risk of major cardiovascular events. These results support a favorable role for LA in CVD prevention.
dc.language.isoENen_US
dc.subject.enLEHA
dc.title.enBiomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality
dc.title.alternativeCirculationen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1161/circulationaha.118.038908en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30971107en_US
bordeaux.journalCirculationen_US
bordeaux.page2422-2436en_US
bordeaux.volume139en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue21en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03209285
hal.version1
hal.date.transferred2021-04-27T08:27:05Z
hal.exporttrue
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