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Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

dc.rights.licenseopenen_US
dc.contributor.authorGIRI, A.
dc.contributor.authorHELLWEGE, J. N.
dc.contributor.authorKEATON, J. M.
dc.contributor.authorPARK, J.
dc.contributor.authorQIU, C.
dc.contributor.authorWARREN, H. R.
dc.contributor.authorTORSTENSON, E. S.
dc.contributor.authorKOVESDY, C. P.
dc.contributor.authorSUN, Y. V.
dc.contributor.authorWILSON, O. D.
dc.contributor.authorROBINSON-COHEN, C.
dc.contributor.authorROUMIE, C. L.
dc.contributor.authorCHUNG, C. P.
dc.contributor.authorBIRDWELL, K. A.
dc.contributor.authorDAMRAUER, S. M.
dc.contributor.authorDUVALL, S. L.
dc.contributor.authorKLARIN, D.
dc.contributor.authorCHO, K.
dc.contributor.authorWANG, Y.
dc.contributor.authorEVANGELOU, E.
dc.contributor.authorCABRERA, C. P.
dc.contributor.authorWAIN, L. V.
dc.contributor.authorSHRESTHA, R.
dc.contributor.authorMAUTZ, B. S.
dc.contributor.authorAKWO, E. A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSARGURUPREMRAJ, Muralidharan
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorBOEHNKE, M.
dc.contributor.authorSCOTT, L. J.
dc.contributor.authorLUAN, J.
dc.contributor.authorZHAO, J. H.
dc.contributor.authorWILLEMS, S. M.
dc.contributor.authorTHERIAULT, S.
dc.contributor.authorSHAH, N.
dc.contributor.authorOLDMEADOW, C.
dc.contributor.authorALMGREN, P.
dc.contributor.authorLI-GAO, R.
dc.contributor.authorVERWEIJ, N.
dc.contributor.authorBOUTIN, T. S.
dc.contributor.authorMANGINO, M.
dc.contributor.authorNTALLA, I.
dc.contributor.authorFEOFANOVA, E.
dc.contributor.authorSURENDRAN, P.
dc.contributor.authorCOOK, J. P.
dc.contributor.authorKARTHIKEYAN, S.
dc.contributor.authorLAHROUCHI, N.
dc.contributor.authorLIU, C.
dc.contributor.authorSEPULVEDA, N.
dc.contributor.authorRICHARDSON, T. G.
dc.contributor.authorKRAJA, A.
dc.contributor.authorAMOUYEL, Philippe
dc.contributor.authorFARRALL, M.
dc.contributor.authorPOULTER, N. R.
dc.contributor.authorLAAKSO, M.
dc.contributor.authorZEGGINI, E.
dc.contributor.authorSEVER, P.
dc.contributor.authorSCOTT, R. A.
dc.contributor.authorLANGENBERG, C.
dc.contributor.authorWAREHAM, N. J.
dc.contributor.authorCONEN, D.
dc.contributor.authorPALMER, C. N. A.
dc.contributor.authorATTIA, J.
dc.contributor.authorCHASMAN, D. I.
dc.contributor.authorRIDKER, P. M.
dc.contributor.authorMELANDER, O.
dc.contributor.authorMOOK-KANAMORI, D. O.
dc.contributor.authorHARST, P. V.
dc.contributor.authorCUCCA, F.
dc.contributor.authorSCHLESSINGER, D.
dc.contributor.authorHAYWARD, C.
dc.contributor.authorSPECTOR, T. D.
dc.contributor.authorJARVELIN, M. R.
dc.contributor.authorHENNIG, B. J.
dc.contributor.authorTIMPSON, N. J.
dc.contributor.authorWEI, W. Q.
dc.contributor.authorSMITH, J. C.
dc.contributor.authorXU, Y.
dc.contributor.authorMATHENY, M. E.
dc.contributor.authorSIEW, E. E.
dc.contributor.authorLINDGREN, C.
dc.contributor.authorHERZIG, K. H.
dc.contributor.authorDEDOUSSIS, G.
dc.contributor.authorDENNY, J. C.
dc.contributor.authorPSATY, B. M.
dc.contributor.authorHOWSON, J. M. M.
dc.contributor.authorMUNROE, P. B.
dc.contributor.authorNEWTON-CHEH, C.
dc.contributor.authorCAULFIELD, M. J.
dc.contributor.authorELLIOTT, P.
dc.contributor.authorGAZIANO, J. M.
dc.contributor.authorCONCATO, J.
dc.contributor.authorWILSON, P. W. F.
dc.contributor.authorTSAO, P. S.
dc.contributor.authorVELEZ EDWARDS, D. R.
dc.contributor.authorSUSZTAK, K.
dc.contributor.authorMILLION VETERAN, Program
dc.contributor.authorO'DONNELL, C. J.
dc.contributor.authorHUNG, A. M.
dc.contributor.authorEDWARDS, T. L.
dc.date.accessioned2020-06-29T08:39:03Z
dc.date.available2020-06-29T08:39:03Z
dc.date.issued2019-01
dc.identifier.issn1546-1718 (Electronic) 1061-4036 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8257
dc.description.abstractEnIn this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.
dc.language.isoENen_US
dc.subject.enVINTAGE
dc.title.enTrans-ethnic association study of blood pressure determinants in over 750,000 individuals
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41588-018-0303-9en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30578418en_US
bordeaux.journalNature Geneticsen_US
bordeaux.page51-62en_US
bordeaux.volume51en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03212226
hal.version1
hal.date.transferred2021-04-29T12:16:59Z
hal.exporttrue
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