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Pesticide use and risk of non-Hodgkin lymphoid malignancies in agricultural cohorts from France, Norway and the USA: a pooled analysis from the AGRICOH consortium

dc.rights.licenseopenen_US
dc.contributor.authorLEON, Maria E.
dc.contributor.authorSCHINASI, Leah H.
dc.contributor.authorLEBAILLY, Pierre
dc.contributor.authorBEANE FREEMAN, Laura E.
dc.contributor.authorNORDBY, Karl-Christian
dc.contributor.authorFERRO, Gilles
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMONNEREAU, Alain
dc.contributor.authorBROUWER, Maartje
dc.contributor.authorTUAL, Severine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBALDI, Isabelle
dc.contributor.authorKJAERHEIM, Kristina
dc.contributor.authorHOFMANN, Jonathan N.
dc.contributor.authorKRISTENSEN, Petter
dc.contributor.authorKOUTROS, Stella
dc.contributor.authorSTRAIF, Kurt
dc.contributor.authorKROMHOUT, Hans
dc.contributor.authorSCHUZ, Joachim
dc.date.accessioned2020-06-26T08:20:47Z
dc.date.available2020-06-26T08:20:47Z
dc.date.issued2019-10-01
dc.identifier.issn1464-3685 (Electronic) 0300-5771 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8211
dc.description.abstractEnBACKGROUND: Pesticides are commonly used in agriculture, and previous studies endorsed the need to further investigate the possible association between their use and risk of lymphoid malignancies in agricultural workers. METHODS: We investigated the relationship of ever use of 14 selected pesticide chemical groups and 33 individual active chemical ingredients with non-Hodgkin lymphoid malignancies (NHL) overall or major subtypes, in a pooled analysis of three large agricultural worker cohorts. Pesticide use was derived from self-reported history of crops cultivated combined with crop-exposure matrices (France and Norway) or self-reported lifetime use of active ingredients (USA). Cox regression models were used to estimate cohort-specific hazard ratios (HRs) and 95% confidence intervals (CIs), which were combined using random effects meta-analysis to calculate meta-HRs. RESULTS: During follow-up, 2430 NHL cases were diagnosed in 316 270 farmers accruing 3 574 815 person-years under risk. Most meta-HRs suggested no association. Moderately elevated meta-HRs were seen for: NHL and ever use of terbufos (meta-HR = 1.18, 95% CI: 1.00-1.39); chronic lymphocytic leukaemia/small lymphocytic lymphoma and deltamethrin (1.48, 1.06-2.07); and diffuse large B-cell lymphoma and glyphosate (1.36, 1.00-1.85); as well as inverse associations of NHL with the broader groups of organochlorine insecticides (0.86, 0.74-0.99) and phenoxy herbicides (0.81, 0.67-0.98), but not with active ingredients within these groups, after adjusting for exposure to other pesticides. CONCLUSIONS: Associations of pesticides with NHL appear to be subtype- and chemical-specific. Non-differential exposure misclassification was an important limitation, showing the need for refinement of exposure estimates and exposure-response analyses.
dc.language.isoENen_US
dc.subject.enEPICENE
dc.title.enPesticide use and risk of non-Hodgkin lymphoid malignancies in agricultural cohorts from France, Norway and the USA: a pooled analysis from the AGRICOH consortium
dc.title.alternativeInt J Epidemiolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ije/dyz017en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30880337en_US
bordeaux.journalInternational journal of epidemiologyen_US
bordeaux.page1519-1535en_US
bordeaux.volume48en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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