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Diet-Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort

dc.rights.licenseopenen_US
dc.contributor.authorLOW, D. Y.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFEVRE ARBOGAST, Sophie
dc.contributor.authorGONZALEZ-DOMINGUEZ, R.
dc.contributor.authorURPI-SARDA, M.
dc.contributor.authorMICHEAU, P.
dc.contributor.authorPETERA, M.
dc.contributor.authorCENTENO, D.
dc.contributor.authorDURAND, S.
dc.contributor.authorPUJOS-GUILLOT, E.
dc.contributor.authorKOROSI, A.
dc.contributor.authorLUCASSEN, P. J.
dc.contributor.authorAIGNER, L.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPROUST-LIMA, Cecile
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHEJBLUM, Boris
ORCID: 0000-0003-0646-452X
IDREF: 189970316
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorANDRES-LACUEVA, C.
dc.contributor.authorTHURET, S.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.contributor.authorMANACH, C.
dc.date.accessioned2020-06-26T08:10:47Z
dc.date.available2020-06-26T08:10:47Z
dc.date.issued2019-09
dc.identifier.issn1613-4133 (Electronic) 1613-4125 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8209
dc.description.abstractEnSCOPE: Untargeted metabolomics may reveal preventive targets in cognitive aging, including within the food metabolome. METHODS AND RESULTS: A case-control study nested in the prospective Three-City study included participants aged >/=65 years and initially free of dementia. We contrasted 209 cases of cognitive decline and 209 controls (matched for age, gender and educational level) with slower cognitive decline over up to 12 years. This article is protected by copyright. All rights reserved Using a bootstrap-enhanced LASSO regression on the baseline serum metabolomes analyzed with LC-QTOF, we identified a signature of 22 metabolites associated with subsequent cognitive decline. The signature included three coffee metabolites, a biomarker of citrus intake, a cocoa metabolite, two metabolites putatively derived from fish and wine, three medium-chain acylcarnitines, glycodeoxycholic acid, lysoPC(18:3), trimethyllysine, glucose, cortisol, creatinine and arginine. Adding the 22 metabolites to a reference predictive model for cognitive decline (conditioned on age, gender and education and including ApoE-epsilon4, diabetes, BMI and number of medications) substantially increased the predictive performance: cross-validated Area Under the Receiver Operating Curve = 75% [95% CI 70-80%] compared to 62% [95% CI 56-67%]. CONCLUSIONS: Our untargeted metabolomics study supports a protective role of specific foods (e.g., coffee, cocoa, fish) and various alterations in the endogenous metabolism responsive to diet in cognitive aging.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enBiostatistics
dc.subject.enLEHA
dc.subject.enSISTM
dc.title.enDiet-Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort
dc.title.alternativeMol Nutr Food Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/mnfr.201900177en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31218777en_US
bordeaux.journalMolecular nutrition & food researchen_US
bordeaux.pagee1900177en_US
bordeaux.volume63en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue18en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSISTM_BPH
bordeaux.teamLEHA_BPH
bordeaux.teamBIOSTAT_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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