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Laboratory Findings, Compassionate Use of Favipiravir, and Outcome in Patients With Ebola Virus Disease, Guinea, 2015-A Retrospective Observational Study

dc.rights.licenseopenen_US
dc.contributor.authorKERBER, R.
dc.contributor.authorLORENZ, E.
dc.contributor.authorDURAFFOUR, S.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSISSOKO, Daouda
dc.contributor.authorRUDOLF, M.
dc.contributor.authorJAEGER, A.
dc.contributor.authorCISSE, S. D.
dc.contributor.authorCAMARA, A. M.
dc.contributor.authorMIRANDA, O.
dc.contributor.authorCASTRO, C. M.
dc.contributor.authorAKOI BORE, J.
dc.contributor.authorRAYMOND KOUNDOUNO, F.
dc.contributor.authorREPITS, J.
dc.contributor.authorAFROUGH, B.
dc.contributor.authorBECKER-ZIAJA, B.
dc.contributor.authorHINZMANN, J.
dc.contributor.authorMERTENS, M.
dc.contributor.authorVITORIANO, I.
dc.contributor.authorHUGH LOGUE, C.
dc.contributor.authorBOTTCHER, J. P.
dc.contributor.authorPALLASCH, E.
dc.contributor.authorSACHSE, A.
dc.contributor.authorBAH, A.
dc.contributor.authorCABEZA-CABRERIZO, M.
dc.contributor.authorNITZSCHE, K.
dc.contributor.authorKUISMA, E.
dc.contributor.authorMICHEL, J.
dc.contributor.authorHOLM, T.
dc.contributor.authorZEKENG, E. G.
dc.contributor.authorCOWLEY, L. A.
dc.contributor.authorGARCIA-DORIVAL, I.
dc.contributor.authorHETZELT, N.
dc.contributor.authorBAUM, J. H. J.
dc.contributor.authorPORTMANN, J.
dc.contributor.authorCARTER, L.
dc.contributor.authorYENAMABERHAN, R. L.
dc.contributor.authorCAMINO, A.
dc.contributor.authorENKIRCH, T.
dc.contributor.authorSINGETHAN, K.
dc.contributor.authorMEISEL, S.
dc.contributor.authorMAZZARELLI, A.
dc.contributor.authorKOSGEI, A.
dc.contributor.authorKAFETZOPOULOU, L.
dc.contributor.authorRICKETT, N. Y.
dc.contributor.authorPATRONO, L. V.
dc.contributor.authorGHEBREGHIORGHIS, L.
dc.contributor.authorARNOLD, U.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOLIN, Geraldine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorJUCHET, Sylvain
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEVY-MARCHAL, Claire
dc.contributor.authorKOLIE, J. S.
dc.contributor.authorBEAVOGUI, A. H.
dc.contributor.authorWURR, S.
dc.contributor.authorBOCKHOLT, S.
dc.contributor.authorKRUMKAMP, R.
dc.contributor.authorMAY, J.
dc.contributor.authorSTOECKER, K.
dc.contributor.authorFLEISCHMANN, E.
dc.contributor.authorIPPOLITO, G.
dc.contributor.authorCARROLL, M. W.
dc.contributor.authorKOIVOGUI, L.
dc.contributor.authorMAGASSOUBA, N.
dc.contributor.authorKEITA, S.
dc.contributor.authorGURRY, C.
dc.contributor.authorDRURY, P.
dc.contributor.authorDIALLO, B.
dc.contributor.authorFORMENTY, P.
dc.contributor.authorWOLFEL, R.
dc.contributor.authorCARO, A. D.
dc.contributor.authorGABRIEL, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorANGLARET, Xavier
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMALVY, Denis
dc.contributor.authorGUNTHER, S.
dc.date.accessioned2020-06-25T08:50:25Z
dc.date.available2020-06-25T08:50:25Z
dc.date.issued2019-06-19
dc.identifier.issn1537-6613 (Electronic) 0022-1899 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8187
dc.description.abstractEnBACKGROUND: In 2015, the laboratory at the Ebola treatment center in Coyah, Guinea, confirmed Ebola virus disease (EVD) in 286 patients. Cycle threshold (Ct) in the Ebola virus RT-PCR and 13 blood chemistry parameters were measured on admission and during hospitalization. Favipiravir treatment was offered to EVD patients on compassionate use basis. METHODS: To reduce biases in the raw field data, we carefully selected 163 of the 286 EVD patients for a retrospective study to assess associations between potential risk factors, alterations in blood chemistry, favipiravir treatment, and outcome. RESULTS: The case fatality rate in favipiravir-treated patients was lower than in untreated patients (31/73 [42.5%] vs. 52/90 [57.8%], p = 0.053 in univariate analysis). In the multivariate regression analysis, higher Ct value and younger age were associated with survival (p <0.001), while favipiravir treatment showed no statistically significant effect (p = 0.11). However, Kaplan-Meier analysis indicated a longer survival time in the favipiravir-treated group (p = 0.015). The study also showed characteristic changes in blood chemistry in fatal cases vs. survivors. CONCLUSIONS: Consistent with the JIKI trial, this retrospective study reveals a trend toward improved survival in favipiravir-treated patients; however, the effect was not statistically significant except for survival time.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.enIDLIC
dc.title.enLaboratory Findings, Compassionate Use of Favipiravir, and Outcome in Patients With Ebola Virus Disease, Guinea, 2015-A Retrospective Observational Study
dc.title.alternativeJ Infect Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/infdis/jiz078en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30788508en_US
bordeaux.journalJournal of Infectious Diseasesen_US
bordeaux.page195-202en_US
bordeaux.volume220en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03209953
hal.version1
hal.date.transferred2021-04-27T13:41:50Z
hal.exporttrue
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