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Cumulative risk and protection effect of serotonergic genes on male antisocial behaviour: results from a prospective cohort assessed in adolescence and early adulthood

dc.rights.licenseopenen_US
dc.contributor.authorLANGEVIN, Stephanie
dc.contributor.authorMASCHERETTI, Sara
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOTE, Sylvana
ORCID: 0000-0001-7944-0647
dc.contributor.authorVITARO, Frank
dc.contributor.authorBOIVIN, Michel
dc.contributor.authorTURECKI, Gustavo
dc.contributor.authorTREMBLAY, Richard
dc.contributor.authorOUELLET-MORIN, Isabelle
dc.date.accessioned2020-06-24T09:00:33Z
dc.date.available2020-06-24T09:00:33Z
dc.date.issued2019-03
dc.identifier.issn0007-1250en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8134
dc.description.abstractEnBACKGROUND: Heritability of antisocial behaviour is estimated at approximately 50% and involves multiple genes.AimsTo investigate the cumulative genetic effects of 116 single nucleotide polymorphisms mapping to 11 candidate serotonergic genes and antisocial behaviours, in adolescence and in early adulthood. METHOD: Participants were 410 male members of the Quebec Longitudinal Study of Kindergarten Children, a population-based cohort followed up prospectively from age 6 to age 23. The serotonergic genes were selected based on known physiological processes and prior associations with antisocial behaviours. Antisocial behaviours were self-reported and assessed by using semi-structured interviews in adolescence and in adulthood. RESULTS: Cumulative, haplotype-based contributions of serotonergic genes conferring risk and protection for antisocial behaviours were detected by using multilocus genetic profile risk scores (MGPRSs) and multilocus genetic profile protection scores (MGPPSs). Cumulatively, haplotype-based MGPRSs and MGPPSs contributed to 9.6, 8.5 and 15.2% of the variance in general delinquency in adolescence, property/violent crimes in early adulthood and physical partner violence in early adulthood, respectively. CONCLUSIONS: This study extends previous research by showing a cumulative effect of multiple haplotypes conferring risk and protection to antisocial behaviours in adolescence and early adulthood. The findings further support the relevance of concomitantly considering multiple serotonergic polymorphisms to better understand the genetic aetiology of antisocial behaviours. Future studies should investigate the interplay between risk and protective haplotype-based multilocus genetic profile scores with the environment. DECLARATION OF INTEREST: I.O.-M. holds a Canada Research Chair in the developmental origins of vulnerability and resilience.
dc.language.isoENen_US
dc.subject.enHEALTHY
dc.title.enCumulative risk and protection effect of serotonergic genes on male antisocial behaviour: results from a prospective cohort assessed in adolescence and early adulthood
dc.title.alternativeBr J Psychiatryen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1192/bjp.2018.251en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30774060en_US
bordeaux.journalThe British Journal of Psychiatryen_US
bordeaux.page137-145en_US
bordeaux.volume214en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03209406
hal.version1
hal.date.transferred2021-04-27T08:58:52Z
hal.exporttrue
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