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Stunting and growth velocity of adolescents with perinatally acquired HIV: differential evolution for males and females. A multiregional analysis from the IeDEA global paediatric collaboration

dc.rights.licenseopenen_US
dc.contributor.authorJESSON, J.
dc.contributor.authorSCHOMAKER, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMALASTESTE, Karine
dc.contributor.authorWATI, D. K.
dc.contributor.authorKARIMINIA, A.
dc.contributor.authorSYLLA, M.
dc.contributor.authorKOUADIO, K.
dc.contributor.authorSAWRY, S.
dc.contributor.authorMUBIANA-MBEWE, M.
dc.contributor.authorAYAYA, S.
dc.contributor.authorVREEMAN, R.
dc.contributor.authorMCGOWAN, C. C.
dc.contributor.authorYOTEBIENG, M.
dc.contributor.authorLEROY, V.
dc.contributor.authorDAVIES, M. A.
dc.date.accessioned2020-06-24T07:54:23Z
dc.date.available2020-06-24T07:54:23Z
dc.date.issued2019-11
dc.identifier.issn1758-2652en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8124
dc.description.abstractEnINTRODUCTION: Stunting is a key issue for adolescents with perinatally acquired HIV (APH) that needs to be better understood. As part of the IeDEA multiregional consortium, we described growth evolution during adolescence for APH on antiretroviral therapy (ART). METHODS: We included data from sub-Saharan Africa, the Asia-Pacific, and the Caribbean, Central and South America regions collected between 2003 and 2016. Adolescents on ART, reporting perinatally acquired infection or entering HIV care before 10 years of age, with at least one height measurement between 10 and 16 years of age, and followed in care until at least 14 years of age were included. Characteristics at ART initiation and at 10 years of age were compared by sex. Correlates of growth defined by height-for-age z-scores (HAZ) between ages 10 and 19 years were studied separately for males and females, using linear mixed models. RESULTS: Overall, 8737 APH were included, with 46% from Southern Africa. Median age at ART initiation was 8.1 years (interquartile range (IQR) 6.1 to 9.6), 50% were females, and 41% were stunted (HAZ<-2 SD) at ART initiation. Males and females did not differ by age and stunting at ART initiation, CD4 count over time or retention in care. At 10 years of age, 34% of males were stunted versus 39% of females (p < 0.001). Females had better subsequent growth, resulting in a higher prevalence of stunting for males compared to females by age 15 (48% vs. 25%) and 18 years (31% vs. 15%). In linear mixed models, older age at ART initiation and low CD4 count were associated with poor growth over time (p < 0.001). Those stunted at 10 years of age or at ART initiation had the greatest growth improvement during adolescence. CONCLUSIONS: Prevalence of stunting is high among APH worldwide. Substantial sex-based differences in growth evolution during adolescence were observed in this global cohort, which were not explained by differences in age of access to HIV care, degree of immunosuppression or region. Other factors influencing growth differences in APH, such as differences in pubertal development, should be better documented, to guide further research and inform interventions to optimize growth and health outcomes among APH.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/us/
dc.subject.enIDLIC
dc.title.enStunting and growth velocity of adolescents with perinatally acquired HIV: differential evolution for males and females. A multiregional analysis from the IeDEA global paediatric collaboration
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/jia2.25412en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31702088en_US
bordeaux.journalAIDS. Official journal of the international AIDS Societyen_US
bordeaux.pagee25412en_US
bordeaux.volume22en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03211522
hal.version1
hal.date.transferred2021-04-28T15:42:21Z
hal.exporttrue
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=AIDS.%20Official%20journal%20of%20the%20international%20AIDS%20Society&amp;rft.date=2019-11&amp;rft.volume=22&amp;rft.issue=11&amp;rft.spage=e25412&amp;rft.epage=e25412&amp;rft.eissn=1758-2652&amp;rft.issn=1758-2652&amp;rft.au=JESSON,%20J.&amp;SCHOMAKER,%20M.&amp;MALASTESTE,%20Karine&amp;WATI,%20D.%20K.&amp;KARIMINIA,%20A.&amp;rft.genre=article


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