Retention in Care Trajectories of HIV-Positive Individuals Participating in a Universal Test-and-Treat Program in Rural South Africa (ANRS 12249 TasP Trial)
| dc.rights.license | open | en_US |
| dc.contributor.author | GOSSET, A. | |
| dc.contributor.author | PROTOPOPESCU, C. | |
| dc.contributor.author | LARMARANGE, J. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | ORNE-GLIEMANN, Joanna | |
| dc.contributor.author | MCGRATH, N. | |
| dc.contributor.author | PILLAY, D. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DABIS, Francois | |
| dc.contributor.author | IWUJI, C. | |
| dc.contributor.author | BOYER, S. | |
| dc.date.accessioned | 2020-06-23T07:40:29Z | |
| dc.date.available | 2020-06-23T07:40:29Z | |
| dc.date.issued | 2019-04-01 | |
| dc.identifier.issn | 1944-7884 (Electronic) 1525-4135 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/8086 | |
| dc.description.abstractEn | OBJECTIVE: To study retention in care (RIC) trajectories and associated factors in patients eligible for antiretroviral therapy (ART) in a universal test-and-treat setting (TasP trial, South Africa, 2012-2016). DESIGN: A cluster-randomized trial whereby individuals identified HIV positive after home-based testing were invited to initiate ART immediately (intervention) or following national guidelines (control). METHODS: Exiting care was defined as >/=3 months late for a clinic appointment, transferring elsewhere, or death. Group-based trajectory modeling was performed to estimate RIC trajectories over 18 months and associated factors in 777 ART-eligible patients. RESULTS: Four RIC trajectory groups were identified: (1) group 1 "remained" in care (reference, n = 554, 71.3%), (2) group 2 exited care then "returned" after [median (interquartile range)] 4 (3-9) months (n = 40, 5.2%), (3) group 3 "exited care rapidly" [after 4 (4-6) months, n = 98, 12.6%], and (4) group 4 "exited care later" [after 11 (9-13) months, n = 85, 10.9%]. Group 2 patients were less likely to have initiated ART within 1 month and more likely to be male, young (<29 years), without a regular partner, and to have a CD4 count >350 cells/mm. Group 3 patients were more likely to be women without social support, newly diagnosed, young, and less likely to have initiated ART within 1 month. Group 4 patients were more likely to be newly diagnosed and aged 39 years or younger. CONCLUSIONS: High CD4 counts at care initiation were not associated with a higher risk of exiting care. Prompt ART initiation and special support for young and newly diagnosed patients with HIV are needed to maximize RIC. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | IDLIC | |
| dc.title.en | Retention in Care Trajectories of HIV-Positive Individuals Participating in a Universal Test-and-Treat Program in Rural South Africa (ANRS 12249 TasP Trial) | |
| dc.title.alternative | J Acquir Immune Defic Syndr | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1097/QAI.0000000000001938 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 30570525 | en_US |
| bordeaux.journal | Journal of acquired immune deficiency syndromes (1999) | en_US |
| bordeaux.page | 375-385 | en_US |
| bordeaux.volume | 80 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
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