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Relation between 20-year income volatility and brain health in midlife: The CARDIA study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGRASSET, Leslie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGLYMOUR, Maria
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorELFASSY, Tali
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSWIFT, Samuel L.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorYAFFE, Kristine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSINGH-MANOUX, Archana
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorZEKI AL HAZZOURI, Adina
dc.date.accessioned2020-06-22T15:26:31Z
dc.date.available2020-06-22T15:26:31Z
dc.date.issued2019-11-12
dc.identifier.issn1526-632X (Electronic) 0028-3878 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8072
dc.description.abstractEnOBJECTIVE: Income volatility presents a growing public health threat. To our knowledge, no previous study examined the relationship among income volatility, cognitive function, and brain integrity. METHODS: We studied 3,287 participants aged 23-35 years in 1990 from the Coronary Artery Risk Development in Young Adults prospective cohort study. Income volatility data were created using income data collected from 1990 to 2010 and defined as SD of percent change in income and number of income drops >/=25% (categorized as 0, 1, or 2+). In 2010, cognitive tests (n = 3,287) and brain scans (n = 716) were obtained. RESULTS: After covariate adjustment, higher income volatility was associated with worse performance on processing speed (beta = -1.09, 95% confidence interval [CI] -1.73 to -0.44) and executive functioning (beta = 2.53, 95% CI 0.60-4.50) but not on verbal memory (beta = -0.02, 95% CI -0.16 to 0.11). Similarly, additional income drops were associated with worse performance on processing speed and executive functioning. Higher income volatility and more income drops were also associated with worse microstructural integrity of total brain and total white matter. All findings were similar when restricted to those with high education, suggesting reverse causation may not explain these findings. CONCLUSION: Income volatility over a 20-year period of formative earning years was associated with worse cognitive function and brain integrity in midlife.
dc.language.isoENen_US
dc.subject.enVINTAGE
dc.title.enRelation between 20-year income volatility and brain health in midlife: The CARDIA study
dc.typeArticle de revueen_US
dc.identifier.doi10.1212/wnl.0000000000008463en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31578298en_US
bordeaux.journalNeurologyen_US
bordeaux.pagee1890-e1899en_US
bordeaux.volume93en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue20en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03211450
hal.version1
hal.date.transferred2021-04-28T15:05:39Z
hal.exporttrue
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