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Risk Factors of Early Kidney Graft Transplantectomy

dc.rights.licenseopenen_US
dc.contributor.authorGUILLAUME, A.
dc.contributor.authorQUERUEL, V.
dc.contributor.authorKABORE, R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFFONDRE, Karen
IDREF: 183599128
dc.contributor.authorCOUZI, L.
dc.contributor.authorMOREAU, K.
dc.contributor.authorBENSADOUN, H.
dc.contributor.authorROBERT, G.
dc.contributor.authorFERRIERE, J. M.
dc.contributor.authorALEZRA, E.
dc.contributor.authorBERNHARD, J. C.
dc.date.accessioned2020-06-22T14:57:54Z
dc.date.available2020-06-22T14:57:54Z
dc.date.issued2019-12
dc.identifier.issn1873-2623 (Electronic) 0041-1345 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8068
dc.description.abstractEnBACKGROUND: Kidney allograft explant in the first month after transplant is a major concern for medicosurgical teams specialized in kidney transplantation and unacceptable graft loss in the current shortage. The aim of our study was to evaluate the risk factors of early kidney graft explant. METHODS: We retrospectively analyzed all adult kidney transplantations performed at our center from January 2006 to December 2011. Recipient, donor, and transplant characteristics were collected, as well as operating data and early postoperative complications. Univariate and multivariate logistic regression models were used to determine risk factors of early renal allograft explant. RESULTS: From a total of 707 kidney transplantations, 28 transplantectomies were performed in the first month following transplantation (3.96%). The average delay in days +/- SD was 7.6 +/- 10. Eighty-six percent of transplantectomies were due to vascular complications. In multivariate analysis, obesity (odds ratio [OR] = 9.6; 95% confidence interval [CI], 1.63-56.5; P = .0007), range of transplantation (OR = 36.89; 95%CI, 5.5-245; P = .0006), intraoperative complications (OR = 3.99; 95%CI, 1.22-13; P = .026), and early postoperative vascular complications (OR = 85.15; 95%CI, 23.6-306; P < .0001) were independent risk factors. Neither donors nor graft characteristics were significant. CONCLUSIONS: Early renal graft transplantectomies are rare but account for 50% of renal graft loss in the first year. Because obesity, perioperative complications, and early vascular complications are independent factors associated with early transplantectomies, their prevention should be based on meticulous surgery during organ procurement, implantation of the kidney, and on the rehabilitation of future recipients.
dc.language.isoENen_US
dc.subject.enBiostatistics
dc.title.enRisk Factors of Early Kidney Graft Transplantectomy
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.transproceed.2019.07.027en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31732213en_US
bordeaux.journalTransplantation Proceedingsen_US
bordeaux.page3309-3314en_US
bordeaux.volume51en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue10en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamBIOSTAT_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03211468
hal.version1
hal.date.transferred2021-04-28T15:14:34Z
hal.exporttrue
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