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Long-term airborne dioxin exposure and breast cancer risk in a case-control study nested within the French E3N prospective cohort

dc.rights.licenseopenen_US
dc.contributor.authorDANJOU, A. M. N.
dc.contributor.authorCOUDON, T.
dc.contributor.authorPRAUD, D.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEVEQUE, Emilie
dc.contributor.authorFAURE, E.
dc.contributor.authorSALIZZONI, P.
dc.contributor.authorLE ROMANCER, M.
dc.contributor.authorSEVERI, G.
dc.contributor.authorMANCINI, F. R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFFONDRE, Karen
IDREF: 183599128
dc.contributor.authorDOSSUS, L.
dc.contributor.authorFERVERS, B.
dc.date.accessioned2020-06-16T07:54:13Z
dc.date.available2020-06-16T07:54:13Z
dc.date.issued2019-03
dc.identifier.issn1873-6750 (Electronic) 0160-4120 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7943
dc.description.abstractEnBACKGROUND: Dioxins, Group 1 carcinogens, are emitted by industrial chlorinated combustion processes and suspected to increase breast cancer risk through receptor-mediated pathways. OBJECTIVES: We estimated breast cancer risk associated with airborne dioxin exposure, using geographic information system (GIS) methods and historical exposure data. METHODS: We designed a case-control study (429 breast cancer cases diagnosed between 1990 and 2008, matched to 716 controls) nested within the E3N (Etude Epidemiologique aupres de femmes de la Mutuelle Generale de l'Education Nationale) cohort. Airborne dioxin exposure was assessed using a GIS-based metric including participants' residential history, technical characteristics of 222 dioxin sources, residential proximity to dioxin sources, exposure duration and wind direction. Odds ratios (OR) and 95% confidence intervals (CI) associated with quintiles of cumulative exposure were estimated using multivariate logistic regression models. RESULTS: We observed no increased risk of breast cancer for higher dioxin exposure levels overall and according to hormone-receptor status. We however observed a statistically significant OR for Q2 versus Q1 overall (1.612, 95% CI: 1.042-2.493) and for estrogen-receptor (ER) positive breast cancer (1.843, 95% CI: 1.033-3.292). CONCLUSIONS: Overall, as well as according to hormone-receptor status, no increased risk was observed for higher airborne dioxin exposure. The increased risk for low exposure levels might be compatible with non-monotonic dose-response relationship. Confirmation of our findings is required. Our GIS-based metric may provide an alternative in absence of ambient dioxin monitoring and may allow assessing exposure to other pollutants.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.enBiostatistics
dc.title.enLong-term airborne dioxin exposure and breast cancer risk in a case-control study nested within the French E3N prospective cohort
dc.title.alternativeEnviron Inten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.envint.2019.01.001en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30658268en_US
bordeaux.journalEnviron Inten_US
bordeaux.page236-248en_US
bordeaux.volume124en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamBIOSTAT_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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