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Sleep disturbances in HIV-HCV coinfected patients: indications for clinical management in the HCV cure era (ANRS CO13 HEPAVIH cohort)

dc.rights.licenseopenen_US
dc.contributor.authorCOSTA, M.
dc.contributor.authorROJAS ROJAS, T.
dc.contributor.authorLACOSTE, D.
dc.contributor.authorVILLES, V.
dc.contributor.authorAUMAITRE, H.
dc.contributor.authorPROTOPOPESCU, C.
dc.contributor.authorYAYA, I.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
dc.contributor.authorKRAUSE, J.
dc.contributor.authorSALMON-CERON, D.
dc.contributor.authorMARCELLIN, F.
dc.contributor.authorSOGNI, P.
dc.contributor.authorCARRIERI, M. P.
dc.date.accessioned2020-06-15T15:22:14Z
dc.date.available2020-06-15T15:22:14Z
dc.date.issued2019-12
dc.identifier.issn1473-5687 (Electronic) 0954-691X (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7933
dc.description.abstractEnOBJECTIVES: Although common among patients coinfected with HIV and hepatitis C virus (HCV), sleep disturbances (SD) are still poorly documented in this population in the HCV cure era. This longitudinal study aimed at analysing SD in HIV-HCV coinfected patients and identifying their clinical and sociobehavioural correlates. METHODS: We used 5-year annual follow-up data from 1047 participants in the French National Agency for Research on Aids and Viral Hepatitis Cohort 13 'Hepatite et VIH' (ANRS CO13 HEPAVIH) cohort of HIV-HCV coinfected patients to identify clinical (medical records) and behavioural (self-administered questionnaires) correlates of SD (mixed-effects logistic regression). SD were identified using one item documenting the occurrence of insomnia or difficulty falling asleep (ANRS 'Action Coordonnee 24' self-reported symptoms checklist), and two items documenting perceived sleep quality (Center for Epidemiologic Studies Depression and WHO Quality of Life HIV-specific brief scales). RESULTS: Seven hundred and sixteen (68.4%) patients with completed self-administered questionnaires reported SD at their most recent follow-up visit. In the multivariable model, hazardous alcohol consumption (Alcohol Use Disorders Identification Test-Consumption score>/=4 for men, >/=3 for women) (adjusted odds ratio=1.61; 95% confidence interval: 1.09-2.36), depressive symptoms (6.78; 4.36-10.55) and the number of other physical and psychological self-reported symptoms (1.10; 1.07-1.13) were associated independently with SD after adjustment for sex, age and employment status. HCV cure was not associated significantly with SD. CONCLUSION: SD remain frequent in HIV-HCV coinfected patients and are associated with a series of modifiable behavioural risk factors. Independent of HCV cure, improved screening and comprehensive management of alcohol use, physical and psychological self-reported symptoms and depression are essential in this population. Closer investigation of these risk factors of SDs may both increase sleep quality and indirectly improve patients' clinical outcomes.
dc.language.isoENen_US
dc.subject.enMORPH3Eus
dc.subject.enANRS CO13 HEPAVIH
dc.title.enSleep disturbances in HIV-HCV coinfected patients: indications for clinical management in the HCV cure era (ANRS CO13 HEPAVIH cohort)
dc.title.alternativeEur J Gastroenterol Hepatolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/meg.0000000000001441en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31094856en_US
bordeaux.journalEur J Gastroenterol Hepatolen_US
bordeaux.page1508-1517en_US
bordeaux.volume31en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Viralesen_US
hal.exportfalse
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