Artificial intelligence for unstructured healthcare data: application to coding of patient reporting of adverse drug reactions
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LETINIER, Louis | |
| dc.contributor.author | JOUGANOUS, Julien | |
| dc.contributor.author | BENKEBIL, Mehdi | |
| dc.contributor.author | BEL-LETOILE, Alicia | |
| dc.contributor.author | GOEHRS, Clement | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SINGIER, Allison | |
| dc.contributor.author | ROUBY, Franck | |
| dc.contributor.author | LACROIX, Clemence | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MIREMONT-SALAME, Ghada | |
| dc.contributor.author | MICALLEF, Joelle | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SALVO, Francesco | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PARIENTE, Antoine
IDREF: 13395711X | |
| dc.date.accessioned | 2021-06-29T10:15:19Z | |
| dc.date.available | 2021-06-29T10:15:19Z | |
| dc.date.issued | 2021-04-18 | |
| dc.identifier.issn | 1532-6535 (Electronic) 0009-9236 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/79325 | |
| dc.description.abstractEn | Adverse drug reaction (ADR) reporting is a major component of drug safety monitoring; its input will however only be optimized if systems can manage to deal with its tremendous flow of information, based primarily on unstructured text fields. The aim of this study was to develop an automated system allowing to code ADRs from patient reports. Our system was based on a knowledge base about drugs, enriched by supervised Machine Learning (ML) models trained on patients reporting data. To train our models, we selected all cases of ADRs reported by patients to a French Pharmacovigilance Centre through a national web-portal between March 2017 - March 2019 (n =2,058 reports). We tested both conventional ML models and deep-learning models. We performed an external validation using a dataset constituted of a random sample of ADRs reported to the Marseille Pharmacovigilance Centre over the same period (n=187). Here we show that regarding AUC and F-measure, the best model to identify ADRs was gradient boosting trees (LGBM), with an AUC of 0.93 [0.92-0.94] and F-measure of 0.72 [0.68 - 0.75]. This model was run for external validation showing an AUC of 0.91 and a F-measure of 0.58. We evaluated an artificial intelligence pipeline that was found able to learn how to identify correctly ADRs from unstructured data. This result allowed us to start a new study using more data to further improve our performance and offer a tool that is useful in practice to efficiently manage drug safety information. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/us/ | * |
| dc.title.en | Artificial intelligence for unstructured healthcare data: application to coding of patient reporting of adverse drug reactions | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/cpt.2266 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 33866552 | en_US |
| bordeaux.journal | Clinical Pharmacology and Therapeutics | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | PharmacoEpi-Drugs | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03273575 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-06-29T10:15:24Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical%20Pharmacology%20and%20Therapeutics&rft.date=2021-04-18&rft.eissn=1532-6535%20(Electronic)%200009-9236%20(Linking)&rft.issn=1532-6535%20(Electronic)%200009-9236%20(Linking)&rft.au=LETINIER,%20Louis&JOUGANOUS,%20Julien&BENKEBIL,%20Mehdi&BEL-LETOILE,%20Alicia&GOEHRS,%20Clement&rft.genre=article |
