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Lifetime occupational exposure proportion estimation methods: a sensitivity analysis in the general population

dc.rights.licenseopenen_US
dc.contributor.authorHOUOT, Marie-Tulin
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHOMERE, Julie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGOULARD, Helene
dc.contributor.authorGARRAS, Loic
dc.contributor.authorDELABRE, Laurene
dc.contributor.authorPILORGET, Corinne
dc.date.accessioned2021-06-29T08:25:11Z
dc.date.available2021-06-29T08:25:11Z
dc.date.issued2021-04-13
dc.identifier.issn0340-0131en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/79313
dc.description.abstractEnOBJECTIVE: To present a sensitivity analysis of the most widely used means of estimating lifetime occupational exposure proportion (LOEP) and their respective impacts on LOEP and population-attributable fraction (PAF) estimates. METHODS: A French population-based sample with full job history (N = 10,010) was linked with four Matgéné job-exposure matrices: flour, cement, silica and benzene. LOEP and the 95% confidence interval were estimated using four methods: the maximum exposure probability during the career (Proba_max), two methods subdividing careers into job-periods (job-period_M1, job-period_M2) and one into job-years (job-year). To quantify differences between methods, percentages of variation were calculated for proportion values and PAF, and compared with published results for France using cross-sectional proportion multiplied by a factor. RESULTS: For each agent, LOEP estimated from the maximum probability during the career (Proba_max) was consistently lower than proportion taking account of job-periods or job-years. LOEP on Proba_max for flour, cement, silica and benzene were, respectively, 4.4% 95% CI (4.0-4.7), 4.3% (3.9-4.6), 6.1% (5.7-6.5) and 3.9% (3.6-4.2). Percentage of variation ranged from 0 to 55.8% according to the agent. The number of cancer cases varied by a twofold factor for exposure to silica and lung cancer and by a fourfold factor for exposure to benzene and acute myeloid lymphoma. CONCLUSIONS: The present study provides a description of several LOEP estimation methods based on exposure assessment over the entire career and describes their impact on PAF. For health monitoring purposes, we recommend to report a range of LOEP with low and high estimates obtained using job-periods (job-period_M1 and job-period_M2).
dc.language.isoENen_US
dc.subject.enJob-exposure matrix (JEM)
dc.subject.enLifetime occupational exposure proportion
dc.subject.enPrevalence
dc.subject.enPopulation-attributable fraction (PAF)
dc.subject.enStatistical method
dc.title.enLifetime occupational exposure proportion estimation methods: a sensitivity analysis in the general population
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00420-021-01691-1en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33847787en_US
bordeaux.journalInternational Archives of Occupational and Environmental Healthen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03273310
hal.version1
hal.date.transferred2021-06-29T08:25:15Z
hal.exporttrue
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