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Residential sources of pesticide exposure during pregnancy and the risks of hypospadias and cryptorchidism: the French ELFE birth cohort

dc.rights.licenseopenen_US
dc.contributor.authorCOGNEZ, N.
dc.contributor.authorWAREMBOURG, C.
dc.contributor.authorZAROS, C.
dc.contributor.authorMETTEN, M. A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBOUVIER, Ghislaine
dc.contributor.authorGARLANTEZEC, R.
dc.contributor.authorCHARLES, M. A.
dc.contributor.authorBERANGER, R.
dc.contributor.authorCHEVRIER, C.
dc.date.accessioned2020-06-15T10:24:48Z
dc.date.available2020-06-15T10:24:48Z
dc.date.issued2019-09
dc.identifier.issn1470-7926 (Electronic) 1351-0711 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7920
dc.description.abstractEnOBJECTIVES: Prenatal occupational exposure to pesticides has been associated with male reproductive tract abnormalities. Little is known about the possible impact of non-occupational pesticide exposure on fetal and child development in the general population. Using data from a nationwide birth cohort, we aimed to assess the association between residential sources of prenatal pesticide exposure and the risks of hypospadias and cryptorchidism. METHODS: Of the 9281 boys in ELFE (French Longitudinal Study of Children), the national French birth cohort, 53 were diagnosed with hypospadias and 137 with cryptorchidism. We assessed residential exposure sources from self-reported domestic use of eight types of pesticide products and French spatial land use data with acreage within a 1000 m radius around each family's home for 21 crop types. We used logistic regression modelling, adjusted for possible confounders that included estimated dietary pesticide intake. Multiple imputations were used to handle missing data. RESULTS: An increased risk of hypospadias was associated with domestic pesticide use against fleas and ticks (OR=2.28, 95% CI 1.09 to 4.75); no associations were found between cryptorchidism and any domestic pesticide use. Slightly increased risks of cryptorchidism were observed in association with all crop acreages near homes during pregnancy, especially for orchards, and no association was observed for hypospadias. CONCLUSIONS: Our results suggest a possible increased risk of hypospadias associated with prenatal use of some domestic pesticide products, likely to contain insecticides, and of cryptorchidism with nearby orchard acreage (crops repeatedly sprayed with pesticides). This work is limited by its modest number of cases.
dc.language.isoENen_US
dc.subject.enEPICENE
dc.title.enResidential sources of pesticide exposure during pregnancy and the risks of hypospadias and cryptorchidism: the French ELFE birth cohort
dc.title.alternativeOccup Environ Meden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/oemed-2019-105801en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31413190en_US
bordeaux.journalOccup Environ Meden_US
bordeaux.page672-679en_US
bordeaux.volume76en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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