Added value of [(18)F]fluorodeoxyglucose positron emission tomography/computed tomography for the diagnosis of post-operative instrumented spine infection
| dc.rights.license | open | en_US |
| dc.contributor.author | FOLLENFANT, E. | |
| dc.contributor.author | BALAMOUTOFF, N. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LAWSON-AYAYI, Sylvie | |
| dc.contributor.author | DUTRONC, H. | |
| dc.contributor.author | DUPON, M. | |
| dc.contributor.author | VITAL, J. M. | |
| dc.contributor.author | DELOBEL, P. | |
| dc.contributor.author | DUROX, H. | |
| dc.contributor.author | DE CLERMONT-GALLERANDE, H. | |
| dc.contributor.author | FERNANDEZ, P. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DAUCHY, Frédéric-Antoine | |
| dc.date.accessioned | 2020-06-11T09:35:38Z | |
| dc.date.available | 2020-06-11T09:35:38Z | |
| dc.date.issued | 2019-07 | |
| dc.identifier.issn | 1778-7254 (Electronic) 1297-319X (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/7879 | |
| dc.description.abstractEn | PURPOSE: Post-operative instrumented spine infection (PISI) is an infrequent complication. Diagnosis of spinal implant infection can be difficult, especially in case of chronic infection. METHODS: This retrospective study attempts to evaluate the diagnostic performance of [18F]fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) in PISI. Imagings were performed between April 2010 and June 2018 among patients referred for suspected chronic spinal implant infection. PET/CT were performed more than 12 weeks after surgery. PET/CT images were re-interpreted independently by two nuclear medicine physicians without knowledge of the patient's conditions. PET/CT data were analyzed both visually and semi-quantitatively (SUVmax). MRI results were collected from medical records. The final diagnosis of infection was based on bacteriological cultures or a twelve-month follow-up. RESULTS: Forty-nine PET/CT were performed in 44 patients (22 women, median age 65.0 years). Twenty-two patients had a diagnosis of infection during follow-up. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for PET/CT were 86.4%, 81.5%, 79.2%, and 88.0%. Sensitivity, specificity, PPV and NPV were 66.7%, 75.0%, 66.0%, 75.0% respectively for MRI and 50.0%, 92.6%, 84.6% and 69.4% for serum C-reactive protein (CRP). Although these values were higher for PET/CT than for MRI or CRP, the differences were not statistically significant. In this setting, false positives with PET/CT can be observed in case of previous spine infection or adjacent segments disc disease. False negatives can result of extensive instrumented arthrodesis or infection with low virulence bacteria. CONCLUSION: PET/CT is useful for the diagnosis of PISI. These results should be evaluated in further prospective study. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | MORPH3Eus | |
| dc.title.en | Added value of [(18)F]fluorodeoxyglucose positron emission tomography/computed tomography for the diagnosis of post-operative instrumented spine infection | |
| dc.title.alternative | Joint Bone Spine | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.jbspin.2019.01.009 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 30711697 | en_US |
| bordeaux.journal | Joint Bone Spine | en_US |
| bordeaux.page | 503-508 | en_US |
| bordeaux.volume | 86 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03209245 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-04-27T08:10:06Z | |
| hal.export | true | |
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