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Microbial Translocation Does Not Drive Immune Activation in Ugandan Children Infected With HIV

dc.rights.licenseopenen_US
dc.contributor.authorFITZGERALD, F. C.
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLHOMME, Edouard
dc.contributor.authorHARRIS, K.
dc.contributor.authorKENNY, J.
dc.contributor.authorDOYLE, R.
dc.contributor.authorKITYO, C.
dc.contributor.authorSHAW, L. P.
dc.contributor.authorABONGOMERA, G.
dc.contributor.authorMUSIIME, V.
dc.contributor.authorCOOK, A.
dc.contributor.authorBROWN, J. R.
dc.contributor.authorBROOKS, A.
dc.contributor.authorOWEN-POWELL, E.
dc.contributor.authorGIBB, D. M.
dc.contributor.authorPRENDERGAST, A. J.
dc.contributor.authorSARAH WALKER, A.
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
dc.contributor.authorKLEIN, N.
dc.contributor.authorTEAM, Chapas- Trial
dc.date.accessioned2020-06-11T08:40:50Z
dc.date.available2020-06-11T08:40:50Z
dc.date.issued2019-01-01
dc.identifier.issn1537-6613 (Electronic) 0022-1899 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7877
dc.description.abstractEnObjective: Immune activation is associated with morbidity/mortality in HIV-infection despite antiretroviral therapy (ART). We investigated whether microbial translocation drives immune activation in HIV-infected Ugandan children. Methods: Nineteen markers of immune activation/inflammation were measured over 96 weeks in HIV-infected Ugandan children in CHAPAS-3 (ISRCTN69078957) and HIV-uninfected age-matched controls. Microbial translocation was assessed using molecular techniques including next-generation sequencing. Results: Of 249 children included, 120 were HIV-infected ART-naive and 22 ART-experienced (median (IQR) age 2.8(1.7-4.0) and 6.5(5.9-9.2) years; median baseline CD4% 20(14-24) and 35(31-39)). 107 were HIV-uninfected controls. Median (IQR) CD4% increase was 17(12-22) at week-96 in ART-naive children, and viral load was<100 copies/mL in 76%/91% ART-naive/experienced. Immune activation decreased with ART. Children could be divided by immune activation markers into clusters: cluster-1 (majority HIV-uninfected); cluster-2 (mixed HIV-uninfected/ART-naive/ART-experienced); and cluster-3 (majority ART-naive). Immune activation was low in cluster-1, decreased in cluster-3, and persisted in cluster-2. Blood microbial DNA levels were negative/very low across groups, with no difference between clusters except Enterobacteriaceae (higher in cluster-1,p<0.0001). Conclusion: Immune activation decreased with ART, with marker-clustering indicating different activation patterns by HIV/ART status. Levels of bacterial DNA in blood were low regardless of HIV/ART/immune activation status. Microbial translocation did not drive immune activation in this setting.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enSISTM
dc.title.enMicrobial Translocation Does Not Drive Immune Activation in Ugandan Children Infected With HIV
dc.title.alternativeJ Infect Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/infdis/jiy495en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30107546en_US
bordeaux.journalJournal of Infectious Diseasesen_US
bordeaux.page89-100en_US
bordeaux.volume219en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSISTM_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03160724
hal.version2
hal.date.transferred2021-03-06T02:39:26Z
hal.exporttrue
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