Diabetic retinopathy in well-controlled type 2 diabetes: Role of glycaemic memory
| dc.rights.license | open | en_US |
| dc.contributor.author | DUCOS, C. | |
| dc.contributor.author | RIGO, M. | |
| dc.contributor.author | LARROUMET, A. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DELYFER, Marie-Noelle | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | KOROBELNIK, Jean-Francois | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MONLUN, Marie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | FOUSSARD, Ninon | |
| dc.contributor.author | POUPON, P. | |
| dc.contributor.author | HAISSAGUERRE, M. | |
| dc.contributor.author | BLANCO, L. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | MOHAMMEDI, Kamel | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | RIGALLEAU, Vincent
IDREF: 069788146 | |
| dc.date.accessioned | 2021-05-21T12:08:08Z | |
| dc.date.available | 2021-05-21T12:08:08Z | |
| dc.date.issued | 2021-02 | |
| dc.identifier.issn | 1262-3636 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/78600 | |
| dc.description.abstractEn | AIMS: As diabetic retinopathy (DR) can occur even in well-controlled patients with type 2 diabetes (T2D), our study sought to determine whether it might be related to 'glucose memory' by evaluating patients' HbA1c over previous years and their skin autofluorescence (SAF). METHODS: In 334 patients with T2D and HbA1c levels≤8%, their available values of HbA1c from previous years were collected, and their SAF measured by an advanced glycation end-product (AGE) reader. Binary logistic regression analysis was then used to correlate DR with previously recorded HbA1c levels and to SAF, with adjustment for DR risk factors [age, gender, BMI, duration of diabetes, arterial hypertension, diabetic kidney disease (DKD), blood lipid levels and statin treatment]. RESULTS: Our patients were mostly men (58.4%) aged 63±10years, with a duration of diabetes of 13±10years and HbA1c=7.1±0.7%. Of these patients, 84 (25.1%) had DR, which was associated with longer duration of diabetes and greater prevalence of DKD. A total of 605 HbA1c values from previous years were collected for time periods -4±3 months (n=255), -16±4months (n=152), -30±4months (n=93) and -62±26 months (n=105). After adjustment, the association between DR and having an HbA1c higher than the median was significant only for the oldest previous HbA1c values: OR=6.75, 95% CI: 1.90-23.90. Moreover, SAF values were higher in those with DR [2.95±0.67 arbitrary units (AU)] vs 2.65±0.65 AU with no DR (P<0.01) and were also associated with the oldest previous HbA1c values (P<0.01). CONCLUSION: Our study found that 25.1% of our well-controlled T2D patients had DR, which was related to both their HbA1c levels from 5years prior to study admission and their SAF values, a marker of glucose memory. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Advanced glycation end-products | |
| dc.subject.en | Diabetes complications | |
| dc.subject.en | Diabetic retinopathy | |
| dc.subject.en | Glycaemic memory | |
| dc.subject.en | Microangiopathy | |
| dc.subject.en | Skin autofluoresence | |
| dc.title.en | Diabetic retinopathy in well-controlled type 2 diabetes: Role of glycaemic memory | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.diabet.2020.03.005 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 32387701 | en_US |
| bordeaux.journal | Diabetes and Metabolism | en_US |
| bordeaux.page | 101156 | en_US |
| bordeaux.volume | 47 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | LEHA_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-03201705 | |
| hal.version | 1 | |
| hal.export | false | |
| workflow.import.source | hal | |
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