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Animal farming and the risk of lymphohaematopoietic cancers: a meta-analysis of three cohort studies within the AGRICOH consortium

dc.rights.licenseopenen_US
dc.contributor.authorEL-ZAEMEY, S.
dc.contributor.authorSCHINASI, L. H.
dc.contributor.authorFERRO, G.
dc.contributor.authorTUAL, S.
dc.contributor.authorLEBAILLY, Pierre
dc.contributor.authorBALDI, Isabelle
dc.contributor.authorNORDBY, K. C.
dc.contributor.authorKJAERHEIM, K.
dc.contributor.authorSCHUZ, J.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMONNEREAU, Alain
dc.contributor.authorBROUWER, M.
dc.contributor.authorKOUTROS, S.
dc.contributor.authorHOFMANN, J.
dc.contributor.authorKRISTENSEN, P.
dc.contributor.authorKROMHOUT, H.
dc.contributor.authorLEON, M. E.
dc.contributor.authorBEANE FREEMAN, L. E.
dc.date.accessioned2020-06-08T09:53:03Z
dc.date.available2020-06-08T09:53:03Z
dc.date.issued2019-11
dc.identifier.issn1470-7926 (Electronic) 1351-0711 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7804
dc.description.abstractEnAnimal farming entails a variety of potential exposures, including infectious agents, endotoxins and pesticides, which may play a role in the aetiology of lymphohaematopoietic cancers (LHCs). The aim of this study was to assess whether farming specific animal species is associated with the risk of overall LHC or its subtypes. Data from three prospective cohort studies in the USA, France and Norway which are part of the Agricultural Cohort consortium and which collected information about animal farming and cancer were used. Analyses included 316 270 farmers and farm workers. Adjusted Cox models were used to investigate the associations of 13 histological subtypes of LHC (n=3282) with self-reported livestock (cattle, pigs and sheep/goats) and poultry (ever/never and numbers raised) farming. Cohort-specific HRs were combined using random-effects meta-analysis. Ever animal farming in general or farming specific animal species was not meta-associated with overall LHC. The risk of myeloid malignancies decreased with increasing number of livestock (p trend=0.01). Increased risk of myeloproliferative neoplasms was seen with increasing number of sheep/goats (p trend <0.01), while a decreased risk was seen with increasing number of livestock (p trend=0.02). Between cohorts, we observed heterogeneity in the association of type of animal farmed and various LHC subtypes. This large-scale study of three prospective agricultural cohorts showed no association between animal farming and LHC risk, but few associations between specific animal species and LHC subtypes were observed. The observed differences in associations by countries warrant further investigations.
dc.language.isoENen_US
dc.subject.enEPICENE
dc.title.enAnimal farming and the risk of lymphohaematopoietic cancers: a meta-analysis of three cohort studies within the AGRICOH consortium
dc.title.alternativeOccup Environ Meden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/oemed-2018-105655en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31302607en_US
bordeaux.journalOccup Environ Meden_US
bordeaux.page827-837en_US
bordeaux.volume76en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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