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High dilated perivascular space burden: a new MRI marker for risk of intracerebral hemorrhage

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUPERRON, Marie-Gabrielle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSCHILLING, Sabrina
dc.contributor.authorZHU, Y. C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSOUMARE, Aicha
dc.contributor.authorMAZOYER, Bernard
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.date.accessioned2020-06-05T13:57:32Z
dc.date.available2020-06-05T13:57:32Z
dc.date.issued2019-09-10
dc.identifier.issn1558-1497 (Electronic) 0197-4580 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/7793
dc.description.abstractEnCommonly observed in older community persons, dilated perivascular spaces (dPVSs) are thought to represent an emerging MRI marker of cerebral small vessel disease, but their clinical significance is uncertain. We examined the longitudinal relationship of dPVS burden with risk of incident stroke, ischemic stroke, and intracerebral hemorrhage (ICH) in the 3C-Dijon population-based study (N = 1678 participants, mean age 72.7 +/- 4.1 years) using Cox regression. dPVS burden was studied as a global score and according to dPVS location (basal ganglia, white matter, hippocampus, brainstem) at the baseline. During a mean follow-up of 9.1 +/- 2.6 years, 66 participants suffered an incident stroke. Increasing global dPVS burden was associated with a higher risk of any incident stroke (hazard ratio [HR], 1.24; 95% CI, [1.06-1.45]) and of incident ICH (HR, 3.12 [1.78-5.47]), adjusting for sex and intracranial volume. Association with ICH remained significant after additionally adjusting for vascular risk factors and for other cerebral small vessel disease MRI markers. High dPVS burden in basal ganglia and hippocampus, but not in white matter or brainstem, were associated with higher risk of any stroke and ICH.
dc.language.isoENen_US
dc.subject.enHEALTHY
dc.subject.enVINTAGE
dc.title.enHigh dilated perivascular space burden: a new MRI marker for risk of intracerebral hemorrhage
dc.title.alternativeNeurobiol Agingen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.neurobiolaging.2019.08.031en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31629114en_US
bordeaux.journalNeurobiology of Agingen_US
bordeaux.page158-165en_US
bordeaux.volume84en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamVINTAGE
bordeaux.teamHEALTHY_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03209868
hal.version1
hal.date.transferred2021-04-27T13:06:29Z
hal.exporttrue
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