Immunotherapy with grass pollen tablets reduces medication dispensing for allergic rhinitis and asthma: A retrospective database study in France
| dc.rights.license | open | en_US |
| dc.contributor.author | DEVILLIER, P. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MOLIMARD, Mathieu | |
| dc.contributor.author | ANSOLABEHERE, X. | |
| dc.contributor.author | BARDOULAT, I. | |
| dc.contributor.author | COULOMBEL, N. | |
| dc.contributor.author | MAUREL, F. | |
| dc.contributor.author | LE JEUNNE, P. | |
| dc.contributor.author | DEMOLY, P. | |
| dc.date.accessioned | 2020-06-05T09:32:45Z | |
| dc.date.available | 2020-06-05T09:32:45Z | |
| dc.date.issued | 2019-07 | |
| dc.identifier.issn | 0105-4538 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/7760 | |
| dc.description.abstractEn | BACKGROUND: Moderate-to-severe allergic rhinitis (AR) may increase the risk of developing or worsening asthma, whereas treatment of AR with subcutaneously or sublingual allergen immunotherapy (SLIT) may slow this progression. METHODS: In a retrospective real-world analysis, prescription fulfilment data were gathered from French retail pharmacies between 1 March 2012 and 31 December 2016. Using linear regression analyses, patients having received at least two prescriptions of grass pollen SLIT tablets over at least 2 successive years were compared with control patients having received symptomatic medications only. RESULTS: A total of 1099 SLIT patients and 27 475 control patients were included in the main analysis. With regard to symptomatic AR medication dispensing, we observed a 50% decrease in the pre-index/follow-up ratio in the SLIT group, a 30% increase in the control group without age matching (P < 0.0001 vs SLIT) and a 20% increase in the control group with age matching (P < 0.0001 vs SLIT). During the follow-up, 11 (1.8%) and 782 (5.3%) patients initiated asthma treatment in the SLIT and control groups, respectively. The relative risk of medication dispensing for new asthma was lower in the SLIT group (by 62.5% [29.1%-80.1%] without age matching (P = 0.0025) and by 63.7% [31.5%-80.7%] with age matching; P = 0.0018). SLIT was also associated with slower progression of asthma medication dispensing during the follow-up period, relative to the control group (regression coefficient: -0.58 [-0.74 to 0.42] without age matching (P < 0.0001) and -0.61 [-0.76 to -0.46] with age matching; P < 0.0001). CONCLUSION: Prescription of grass pollen SLIT tablets reduced the dispensing of AR and asthma medications in real life. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | PharmacoEpi-Drugs | |
| dc.title.en | Immunotherapy with grass pollen tablets reduces medication dispensing for allergic rhinitis and asthma: A retrospective database study in France | |
| dc.title.alternative | Allergy | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/all.13705 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 30589088 | en_US |
| bordeaux.journal | Allergy | en_US |
| bordeaux.page | 1317-1326 | en_US |
| bordeaux.volume | 74 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 7 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Allergy&rft.date=2019-07&rft.volume=74&rft.issue=7&rft.spage=1317-1326&rft.epage=1317-1326&rft.eissn=0105-4538&rft.issn=0105-4538&rft.au=DEVILLIER,%20P.&MOLIMARD,%20Mathieu&ANSOLABEHERE,%20X.&BARDOULAT,%20I.&COULOMBEL,%20N.&rft.genre=article |
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